肺栓塞患者心型脂肪酸结合蛋白水平的变化及临床意义

目的探讨急性肺栓塞(APE)患者心型脂肪酸结合蛋白(H-FABP)浓度的变化及临床意义。方法选择2009年8月至2011年12月在我院诊治的102例APE患者为观察组,同期选择年龄、性别匹配的健康体检者90例为对照组。采用双向侧流免疫法检测H-FABP浓度,比较两组血H-FABP水平以及观察组治疗前后血H-FABP水平、超声心动图、动脉血氧分压的差异。结果观察组血H-FABP浓度为(6.95±4.80)μg/L,对照组为(4.97±2.77)μg/L,两组比较差异有统计学意义(P<0.01)。APE患者治疗前后血H-FABP比较差异有统计学意义(P<0.01),APE患者治疗后右心室舒张末期内径缩小,肺动脉压力下降,动脉血氧分压升高,差异有统计学意义(P<0.01)。结论APE患者血H-FABP浓度升高,有效治疗后浓度下降,观察血H-FABP浓度变化有助于APE的诊断和疗效评估。

The Changes and Its Clinical Significance of Heart-type Fatty Acid-binding Protein Levels in Patients with Acute Pulmonary Embolism

Objective To investigate the changes of plasma heart-type fatty acid-binding protein(H-FABP)and its clinical significance in patients with acute pulmonary embolism(APE).Methods 102 APE cases diagnosed and treated in our hospital during August 2009 to December 2011 were chosen as the observation group,90 healthy people of the matching age and gender for healthy check-up were chosen as the control group.H-FABP concentration were measured by two-way flow immune method,H-FABP blood level was compared and the differences in H-FABP level,echocardiography,arterial oxygen tension before and after treatment were observed.Results The blood H-FABP concentration of the observation group was(6.95±4.80)μg/L,and was(4.97±2.77)μg/L of the control group,statistically significant different(P<0.01).H-FABP blood concentration before treatment and after treatment was significantly different(P<0.01),the right ventricular end-diastolic diameter reduced,pulmonary artery pressure decreased,arterial oxygen pressure increased after treatment with statistical significance(P<0.01).Conclusion The plasma H-FABP levels in APE patients with APE is increased,which decrease after effective treatment,which may be helpful in the diagnosis and effectiveness evaluation of APE.