冠心病患者血B型钠尿肽和纤维蛋白原水平临床意义的研究

目的研究冠心病与B型钠尿肽(BNP)、纤维蛋白原(FIB)的临床关系。方法经冠状动脉造影明确诊断冠心病患者164例,按临床类型分为稳定性心绞痛(SAP)20例,不稳定性心绞痛(UAP)64例,急性心肌梗死(AMI)80例,另选取同期健康对照组20例。于发病6～24 h内抽取清晨空腹静息状态下静脉血检测BNP、FIB,并进行比较。采用Judkins法评定冠状动脉病变程度,采用Gensini积分系统衡量冠状动脉病变程度,并与BNP、FIB进行相关分析。结果在冠心病临床分型中AMI组、UAP组、SAP组BNP、FIB明显高于对照组,差异有统计学意义(P<0.05)。病变血管支数分组中三组FIB比较差异有统计学意义(P<0.05)。合并疾病分组BNP水平比较差异有统计学意义(P<0.05)。冠心病临床分型各组Gensini评分与BNP、FIB无相关性(P>0.05)。结论 BNP与FIB水平与冠心病临床分型相关,BNP与病变血管支数无明显相关性。

Study of Clinical Significance Blood B-Type Natriuretic Peptide and Fibrinogen Levels of Patients with Coronary Heart Disease

Objective To study the correlation between coronary heart disease and B-Type natriuretic peptide(BNP),fibrinogen(FIB).Methods 164 cases with coronary artery disease diagnosed by coronary angiography were divided into three groups according to the clinical type,20 cases of stable angina pectoris(SAP),64 cases of unstable angina pectoris(UAP),80 cases of acute myocardial infarction(AMI),and another 20 healthy cases were selected as the control group.Resting fasting venous blood measurements of BNP,FIB were tested within 6-24 h of the onset and compared.Judkins method was adopted to assess the severity of coronary lesions,and Gensini score system was used to measure the severity of coronary lesions,and correlation analysis of BNP and FIB was done.Results BNP,FIB of AMI group,UAP group,and SAP group were higher than the control group,the difference was statistically significant(P<0.05).Among the three group:single-vessel disease group,two-vessel disease,three-vessel disease group divided by leasion count,the differences in FIB level was statistically significant(P<0.05).Merger disease group BNP levels had statistically significant difference(P<0.05).Among groups by coronary heart disease clinical classification,Gensini score and BNP,FIB showed no correlation(P>0.05).Conclusion The levels of FIB and BNP were correlated with the clinical classification of coronary heart disease,while no obvious correlation between BNP and coronary lesions count was observed.