痛风发病机制的研究进展

痛风是一种急性炎症性关节炎,可以完全破坏关节的完整性甚至引起重度残疾。另外,痛风能够加速动脉粥样硬化,最后导致患心血管疾病的风险增加。虽然,痛风与高血压、脑卒中以及慢性心血管疾病相关,但血清尿酸水平作为心血管疾病的独立危险因素,目前具体致病机制尚不清楚。现简要综述痛风的临床表现和目前治疗现状,以及痛风的发病机制研究进展。

Research Development in Pathogenesis of Gout

Gout is an acute inflammatory arthritis with the potency to fully destroy the integrity of the joint leading to severe disability.Besides joint destruction,gout is often associated with an accelerated atherosclerosis resulting in an increased risk of cardiovascular disease.The role of serum uric acid as an independent risk factor for cardiovascular disease remains unclear although hyperuricemia is associated with cardiovascular disease such as hypertension,stroke and chronic cardiovascular diseases.Here is to make a brief review on the modes of clinical manifestations,the current knowledge about treatment and the pathogenesis of grout.