| 犬快速肺静脉起搏心房颤动模型中基质金属蛋白酶在肺静脉肌袖表达的实验研究 |
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| 引用本文： | 赵子文,郑强荪,薛玉生,王彬,洪昌明,刘雄涛,张敬.犬快速肺静脉起搏心房颤动模型中基质金属蛋白酶在肺静脉肌袖表达的实验研究[J].西南国防医药,2008,18(2):165-168. |
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| 作者姓名： | 赵子文 郑强荪 薛玉生 王彬 洪昌明 刘雄涛 张敬 |
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| 作者单位： | 第四军医大学唐都医院心内科,陕西,西安,710038 |
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| 基金项目： | 陕西省自然科学基金(2005C216) |
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| 摘 要： | 目的：探讨基质金属蛋白酶-9（MMP-9）和组织型基质金属蛋白酶抑止因子-1（TIMP-1）在持续性房颤发生和维持中的作用。方法：30只犬随机分为对照组和房颤组，建立犬快速肺静脉起搏持续性心房颤动模型。取组织标本，用RT—PCR和Western印记法分别检测各组MMP-9和TLMP-1mRNA和蛋白的表达情况。结果：与对照组相比，房颤组肺静脉肌袖组织MMP-9mRNA与蛋白质水平均增高（P均〈O．05），TIMP-1mRNA与蛋白质表达水平均降低（P均〈O．05）。结论：MMP-9／TIMP-1平衡失调可能是房颤时肺静脉肌袖细胞外基质重构的因素之一，参与了房颤的发生和维持。
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| 关 键 词： | 心房颤动 基质金属蛋白酶-9 组织型基质金属蛋白酶抑止因子-1 肺静脉 肌袖 |
| 文章编号： | 1004-0188(2008)02-0165-04 |
| 修稿时间： | 2007年9月3日 |
Expression of matrix metalloproteinase in pulmonary vein myocardial sleeves in a canine model of persistent atrial fibrillation by rapid pulmonary vein pacing |
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| ZHAO Zi-wen,ZHENG Qiang-sun,XUE Yu-sheng,WANG Bin,HONG Chang-ming,LIU Xiong-tao,ZHANG Jing.Expression of matrix metalloproteinase in pulmonary vein myocardial sleeves in a canine model of persistent atrial fibrillation by rapid pulmonary vein pacing[J].Medical Journal of National Defending forces in Southwest China,2008,18(2):165-168. |
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| Authors: | ZHAO Zi-wen ZHENG Qiang-sun XUE Yu-sheng WANG Bin HONG Chang-ming LIU Xiong-tao ZHANG Jing |
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| Institution: | ZHAO Zi-wen,ZHENG Qiang-sun,XUE Yu-sheng,WANG Bin,HONG Chang-ming,LIU Xiong-tao,ZHANG Jing Department of Cardiology,Tangdu Hospital,Fourth Military Medical University,Xi\'an,710038,China. |
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| Abstract: | Objective:To investigate the effects of MMP-9/TIMP-1(matrix metalloproteinases-9/tissue inhibitor of metalloproteinase-1) on persistent atrial fibrillation(AF).Methods:Thirty dogs were randomly divided into two groups: normal control group(SR, n=15) and atrial fibrillation group(AF, n=15). The model of persistent atrial fibrillation was established by rapid pulmonary vein pacing in dogs. The blood samples were collected from left upper pulmonary veins of these animals. The mRNA and protein expressions of MM... |
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| Keywords: | atrial fibrillation matrix metalloproteinases tissue inhibitor of metalloproteinase pulmonary vein myocardial sleeves |
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