肱骨近端骨密度的测量及其与年龄和体质量指数的相关性研究

目的 建立一种肱骨近端骨密度(BMD)的测量方法,研究肱骨近端BMD与年龄和体质量指数(BMI)的关系,探讨肱骨近端BMD在预报骨质疏松症的敏感性.方法 选择绝经后健康女性志愿者,使用Hologie DELPHI-A双能X射线骨密度仪及本研究设计的肩部定位器和前臂定位器测虽肱骨近端BMD.研究第一部分包括30名忐愿者,每人连续测量右侧肱骨近端BMD 2次,根据测量结果计算短期精密度RMS SD和RMS CV;第二部分包括92名志愿者,记录其年龄、身高、体重,测量右侧肱骨近端BMD,分析肱骨近端BMD与年龄和BMl的相关性.结果 本研究肱骨近端BMD测量方法的短期精密度:RMS SD=0.011 g/cm2,RMS CV=2.4%.本研究92名志愿者平均(60.2±6.4)岁,平均身高(159.5±5.4)cm,平均体质晕(59.4±7.5)kg,平均BMI 23.3±2.7,平均肱骨近端BMD(0.543±0.083)g/cm2,肱骨近端BMD 同年龄呈负相关,同BMI无显著相关.结论 本研究建立了一种测苗肱骨近端BMD的方法;年龄越人肱骨近端BMD越低;由于BMI对BMD的影响会掩盖骨质的丢失,而非负重区域即肱骨近端会最大程度地减少BMI对BMD的影响程度.

Measurement of hone mineral density in the proximal humeral region

Objective To establish a method of measuring bone mineral density (BMD) in the proximal humeral region, and explore the relationship between proximal humeral BMD level and age and body mass index (BMI).Methods A scanning procedure was developed, using a shoulder & forearm position device.Firstly, 30 subjects were examined on the proximal humerus with 2 successive scan sessions to de-termine the short-term precision.Secondly, scanning of the right proximal humerus BMD in 92 healthy women was done.Results Short term precision revealed that RMS SD was 0.011 g/cm2, and RMS CV (coefficient of variation) on BMD measurement was 2.4%.Proximal humeral BMD values decreased with age.No correlation existed between the proximal humeral BMD and BMI.Conclusions The method of measuring BMD over the proximal humeral region is reasonable, and the short term precision of the result is acceptable.Proximal humeral BMD tends to decrease with age.Since the shoulder is subject to the least in-fluence of weight and stress loading, the proximal humeral BMD scan might be an early stage indicator of osteoporosis.