铅的毒性和致癌性研究进展

铅是一种古老的金属,它可引起空气、水、土壤等环境污染。过去的研究表明,铅可引起多系统、多器官的损伤。动物试验表明铅对动物有致癌性,对人类是可能的致癌物,国际癌症联合会将其列入2B类致癌物。该文就目前毒理学研究的热点,即低水平暴露(过去认为是安全的暴露量)的铅对人体健康产生的影响,也就是所谓“亚临床毒性”及致癌性研究进行了综述。

PROGRESS STUDY ON TOXICITY AND CARCINOGENICITY OF LEAD

Lead is an ancient metal. It causes contamination of air, water and soil, locally and worldwide. Lead is toxic to multiple organ systems. It is established animal carcinogen. It is currently considered by the IARS to be a possible human carcinogen(group 2B) on the basis of " sufficient" animal date and " inadequate " human date. It is reviewed that recent research on the toxicology and carcinogenicity of lead has focused on understanding health effects at relatively low levels of exposure. This work has led an understanding of " subclinical toxicity " .