原发性眼眶内脑膜瘤的临床及病理,免疫组化观察

目的 探讨眼眶内原发性脑膜瘤的临床、病理及免疫组化特点。方法 回顾性分析１５例眶内脑膜瘤的临床资料，复习症理切片及免疫组化结果。结果 患者男６例、女９例，４￣５２岁（平均３３．３岁）。主要临床表现为眼球突出、视力严重受损及视神经萎缩。大体病理形态与颅内脑膜瘤相同。２例侵犯眼眶骨质，但核分裂相少。免疫组化阳性率为：ＶＩＭ１００％，ＥＭＡ６０％，ＣＫ４６．６７％，Ｓ１００４０％，ＮＳＥ６０％，ＧＦＡＰ

A clinical,pathologic and immunohistochemistry study of primary orbital meningioma

Objective To probe the clinicl and pathologic and immunohistochemistry features of primary orbital meningioma.Methods To studied the clinical materials of 15 cases of primary orbital meningioma retrospectively.All the pathologic section and immunohistochemistry results of these patients were reviewed as well.Results This series included 6 male and 9 female patients with a ago ranging from 4-to 52-year-old.Exophthalmus,serious vision disorder and optic atrophy were the main clinical manifestations.The pathologic picture appearance of primary orbital meningioma.In two cases,the orbital bone was invaded.The positive rate of immunohistochemistry examination of these cases were:VIM 100%,EMA 60%,CK 46.67%,S 100 40%,NSE 60%,GFPA(-).Conclusion Primary orbital meningioma affected women more than men,with a age younger than that of intracranial meningioma.The mass effect was its main clinical feature.Most primary orbital meningioma manifested as benign tumor pathologically.The immunohistochemistry examination exmination in favorable to differentiate orbital meingioma from glioma.