普伐他汀的非调脂作用

目的观察老年冠心病患者使用普伐他汀治疗8周后,血脂、高敏C反应蛋白（hs CRP）,内皮素（Endotheli-al,ET）的变化。方法对42例伴有高脂血症的老年冠心病患者每日服用10 mg普伐他汀8周,测定其服药前后血脂[总胆固醇（TC）、三酰甘油（TG）,低密度脂蛋白胆固醇（LDL-C）,高密度脂蛋白胆固醇（HDL-C）],hs CRP,ET水平并做统计学分析。结果普伐他汀可有效地降低老年冠心病伴高脂血症患者血脂TC、TG、LDL-C和hs CRP、ET（P<0.01,P<0.05）,HDL-C有较显著升高（P<0.05）,而且普伐他汀引起的血hs CRP、ET的降低分别与TC（r=0.196;r=0.135）、LDL-C（r=0.227;r=0.176,）、TG（r=0.145;r=0.304,P=0.05）的下降之间无相关关系。结论老年冠心病患者服用普伐他汀治疗后,可明显控制血浆hs CRP、ET水平,具有独立于降脂作用之外的抑制炎症,改善内皮功能,稳定斑块的作用。

Effect of Pravastatin on plasma levels of hs CRP, ET in elderly patients with coronary heart disease and its non-lipid function

AIM To observe the changes of plasma levels of high sensitive C-reactive protein(hs CRP) and endothelial(ET) following 8-week administration of Pravastatin in elderly patients with coronary heart disease(CHD).METHODS Forty-two elderly patients with CHD and hyperlipidemia were treated with Pravastatin for 8 weeks.Before and after the treatment,the plasma levels of TC,LDL-C,HDL-C,TG,hs CRP and ET were detected and compared.RESULTS After 8 weeks of treatment,the plasma levels of TC,TG,LDL-C,hs CRP and ET were significantly decreased(P<0.01,P<0.05) while HDL-C increased(P<0.05).There was no relation between the decreasing values of TC,hs CRP and ET and those of TC(r=0.196;r=0.135),LDL-C(r=0.227;r=0.176) and TG(r=0.145;r=0.304 P=0.05).CONCLUSION HMG-COA reductase inhibitors can reduce the levels of inflammatory factors and they may have some non-lipid effects on the inhibitive activities of inflammatory factors,improving the function of vascular endothelium,which may promote the stabilization of atherosclerotic plaque,independent of lipid-lowering effects.