血脂康对2型糖尿病合并颈动脉斑块患者血清内脏脂肪素的影响

目的：通过观察2型糖尿病合并颈动脉斑块患者血清内脏脂肪素（visfatin）水平的变化,探讨visfatin与糖尿病动脉粥样硬化的关系及血脂康对其影响。方法：2型糖尿病无颈动脉斑块患者40例为对照组;2型糖尿病合并颈动脉斑块患者80例随机分为血脂康治疗组40例,辛伐他汀治疗组40例。检测血脂康组和辛伐他汀组与对照组治疗84d前后血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及血清visfatin等指标的改变,并进行临床疗效对比。结果：2型糖尿病合并颈动脉斑块患者的visfatin水平高于无颈动脉斑块对照组（P〈0.05）,但三组间血清TC、TG、LDL-C、HDL-C水平无显著性差异（P〉0.05）;治疗84d后两治疗组血清TC、TG、LDL-C和visfatin水平均较治疗前有明显降低（P〈0.05）,HDL-C也高于治疗前水平（P〈0.05）,但两治疗组间无显著性差异（P〉0.05）。结论：①visfatin可作为检测糖尿病动脉粥样硬化的指标;②在调节血脂水平的同时,血脂康具有与辛伐他汀相似的降低visfatin作用,血脂康可能通过减低visfatin水平来发挥其抗动脉粥样硬化作用。

The Effect of Xuezhikang on Serum Visfatin in Patients with Type 2 Diabetes and Carotid Artery Plaque

Objective：To observe the change of serum visfatin in patients with type 2 diabetes mellitus and carotid artery plaque and to investigate the relationship between visfatin and diabetic atherosclerosis and the effect of Xuezhikang on them.Methods：40 type 2 diabetic patients mellitus without carotid artery plaque were considered as a control group,while 80 type 2 diabetic patients mellitus with carotid artery plaque were randomly divided into Xuezhikang treatment group and simvastatin treatment group,each group had 40 cases.Changes of serum total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C） and serum visfatin were measured and compared before and after 12 weeks of treatment among Xuezhikang group,simvastatin group and control group.Results：Levels of serum visfatin in type 2 diabetic patients with carotid artery plaque were higher than those of control group without carotid artery plaque（P〈0.05）,but levels of serum TC,TG,LDL-C and HDL-C among the three groups were no significant difference（P〈0.05）;serum TC,TG,LDL-C,and visfatin levels of two treatment groups after 12 weeks treatment were significantly lower than those before treatment（P〈0.05）.HDL-C is also higher than before（P〈0.05）.There were no significant difference between two treatment groups（P〈0.05）.Conclusion：visfatin can be used as indicators of diabetic atherosclerosis.At the same time of regulating lipids,Xuezhikang had a similar role with simvastatin in reducing visfatin level.Xuezhikang can exert anti-atherosclerotic effect by reducing the expression of visfatin.