胆汁酸类成分替代中药熊胆的药性分析

目的：探讨熊胆中主要胆汁酸类成分临床代替中药熊胆使用的合理性，分别分析它们和中药熊胆在药性上存在的差异。方法：根据医学典籍对中药熊胆药性的描述，并参考《中药学》总结熊胆的药性；根据CNKI数据库中胆汁酸类成分药理作用研究的相关文献，对主要胆汁酸类成分的药理作用进行梳理和总结；论文根据胆汁酸类成分的药理作用，运用本课题组已建立的药性预测模型，预测各胆汁酸的药性，并将预测结果与熊胆的药性相比较。结果：熊胆中的胆汁酸类成分大部分都有苦寒之性，它们药性的加合可体现熊胆的药性组合。结论：熊胆中的主要胆汁酸类成分均能发挥熊胆的部分作用，临床应用时需要根据具体情况注意调整使用方案。

Analysis on replacement of traditional Chinese medicine bear bile with bile acids based on drug properties

Objective: To discuss the rationality of the clinical replacement of traditional Chinese medicine (TCM) bear bile with bile acid constituents, and analyze the difference between these constituents and bear bile in drug properties. Method: Summarizing the drug properties of bear bile by reference to medical literatures for drug properties of TCM bear bile and Science of Traditional Chinese Medicine (China Press of Traditional Chinese Medicine, 2007). Analyzing and summarizing the pharmacological effects of main bile acid constituents according to relevant literatures for studies on pharmacological effects of main bile acid constituents in CNKI database. Predicating the drug properties of these bile acid constituents by using the drug property predication model established by the study group according the pharmacological effects of main bile acid constituents in the paper, and compare the prediction results with the drug properties of bear bile. Result: Bile acid constituents in bear bile were mostly cold in property, bitter in taste, and the combination of their drug properties could reflect the combined drug properties of bear bile. Conclusion: All of these bile acid constituents in bear bile could show part of effects of bear bile. Attention shall be given to regulate the medication scheme in clinical application according to actual conditions.