壳聚糖复合微胶囊的研制及在维生素D2可控释放中的应用

研究了以壳聚糖为核心壁材，以乙基纤维素为包衣材料的控制释放体系，以．维生素D2为模型药物，采用喷雾干燥方法对其进行有效包覆，并用乙基纤维进行了涂覆。对不同制备方法的微胶囊的形态及释放效果进行了测试。并探讨了制备过程中壳聚糖浓度，壳聚糖分子量，乙酸浓度，维生素D2负载量等因素对药物释放方式的影响。所制备的微胶囊不仅在肠液中具有显著的缓释效果。并且大大降低了维生素D2在胃中的释放，达到肠溶的目的。

Preparation of Complex Chitosan Microcapsule and Its Application in Controlled Release of Vitamin D2

In this work a system which consists of chitosan (CS) microcores entrapped within enteric polymer is presented. Vitamin D 2,used as a model drug, was efficiently entrapped within CS microcores using spray-drying and then microencapsulated into ethylic cellulose(EC). The morphology and release properties of microcapsules were tested. The influential factors of preparation conditions included molecular weight of chitosan, concentration of chitosan solution, concentration of acetic acid, loading of vitamin D 2 were discussed. The results of in vitro release studies showed that the microcapsules prepared in this article could realize sustained release in intestine.