Serum vitamin B12, folate,and homocysteine levels and their association with clinical and electrophysiological parameters in multiple sclerosis |
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| Authors: | B. Kocer S. Engur F. Ak M. Yılmaz |
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| Affiliation: | 1. Isfahan University of Medical Sciences, Isfahan, Iran;2. Isfahan Neuroscience Research Centre, Iran;3. University of Isfahan, Department of Biology, Isfahan, Iran;4. Department of Biostatistics and Epidemiology, Health School, Isfahan University of Medical Sciences, Isfahan, Iran;1. Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland;2. First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland;3. The Nutristasis Unit and the Molecular Haemostasis and Thrombosis Laboratory, Viapath, St. Thomas'' Hospital, London, UK;1. Harvard T.H. Chan School of Public Health, USA;2. NHS Greater Glasgow and Clyde, UK;3. School of Medicine, University of Glasgow, UK;1. Gaziosmanpasa University, School of Medicine, Department of Dermatology, Tokat, Turkey;2. Gaziosmanpasa University, School of Medicine, Department of Medical Biology, Tokat, Turkey;3. Tokat State Hospital, Department of Dermatology, Tokat, Turkey;1. Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy;2. Neurology Unit and MS Centre, Foundation IRCCS Ca'' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy;3. Department of Brain and Behavioral Sciences, University of Pavia, via Forlanini 6, 27100 Pavia, Italy;4. Fondazione Istituto Neurologico Nazionale IRCCS Mondino, via Mondino 2, 27100 Pavia, Italy;5. Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 48 - 20132 Milan, Italy;6. Neurology Unit, San Raffaele Scientific Institute, Via Olgettina 48 - 20132 Milan, Italy;7. Department of Surgical, Pediatric, and Diagnostic Sciences, University of Pavia, Viale Brambilla 74, 27100 Pavia, Italy;8. UOC Anestesia e Rianimazione, IRCCS Policlinico San Matteo, Viale Camillo Golgi 19, 27100 Pavia, Italy;9. Vita-Salute San Raffaele University, Via Olgettina 48 - 20132 Milan, Italy;10. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 48 - 20132 Milan, Italy;11. Neurophisiology Unit, IRCCS San Raffaele Scientific Institute, San Raffaele Scientific Institute, Via Olgettina 48 - 20132 Milan, Italy |
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| Abstract: | Patients with multiple sclerosis (MS) may have low serum vitamin B12 and folate levels and high levels of homocysteine. We aimed to evaluate serum vitamin B12, folate, homocysteine, mean corpuscular volume (MCV), hemoglobin (Hb), and hematocrit (Hct) levels in patients with MS. We examined the relationship between these parameters and age, sex, disease type, age at onset, disease duration, Expanded Disability Status Score, immunoglobulin G (IgG) index, oligoclonal band presence, visual evoked potentials (VEP) and posterior tibial somatosensory evoked potentials (SEP). These parameters were evaluated in 35 patients during an acute attack and compared to data collected from 30 healthy individuals (control subjects). Serum vitamin B12, folate, homocysteine, Hb, and Hct levels and MCV were low in a proportion of patients with MS (20%, 14.3%, 20%, 6.7%, 3.3% and 10% respectively), whereas only vitamin B12 and folate levels were low in only 3.3% of the control subjects. Homocysteine levels were high in 20% of patients with MS but were within normal limits in the control group. Elevated Hct levels were significantly correlated (p < 0.05) with prolonged posterior tibial SEP P1 and P2 latencies compared to the control subjects. Patients with MS who had prolonged VEP and posterior tibial SEP P1 and P2 latencies also had lower vitamin B12 levels compared to patients with normal latencies. Thus, we found a significant relationship between MS and vitamin B12 deficiency, and also demonstrated a relationship between vitamin B12 deficiency, VEP and posterior tibial SEP in MS. |
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