Prediction,clinical characteristics and prognosis of intracerebral hemorrhage in hepatocellular carcinoma patients with intracerebral metastasis |
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| Authors: | Mei-Jen Hsieh Cheng-Hsien Lu Nai-Wen Tsai Chun-Chung Lui Yao-Chung Chuang Chi-Ren Huang Shu-Fang Chen Chiung-Chih Chang Hsueh-Wen Chang Wen-Neng Chang |
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| Institution: | 2. Division of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan;3. Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Japan;1. College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, United States;2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States;3. College of Medicine, University of Cincinnati, Cincinnati, OH, United States;4. Geriatric Research Education and Clinical Center, VA Boston Medical Center, Boston, MA, United States;5. Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States |
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| Abstract: | The clinical characteristics of intracerebral hemorrhage (ICH) in hepatocellular carcinoma (HCC) patients with intracerebral metastasis (IcM) have not been reported on extensively. We compared the clinical characteristics between patients with ICH (w-ICH, 18 patients) and without ICH (wo-ICH, 24 patients) in HCC patients with IcM. Using multivariate logistic regression, only habitual alcohol consumption is a significant predictor of ICH in HCC patients with IcM (adjusted odds ratio OR] = 4.7, 95% CI = 1.26–17.71, p = 0.022). Patients with ICH also had lower Glasgow Coma Scale scores at the time of admission (p = 0.032) and lower incidence of infratentorial metastasis (p = 0.014). Using correlation analysis, only blood platelet count on admission was positively correlated with survival duration after the diagnosis of IcM in the wo-ICH group (p = 0.000) but not in the w-ICH group. |
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