小口径人工血管构建研究现状与展望

人工血管在临床上的需求不断增长,但问题也较普遍,特别是小口径人工血管植入后再狭窄率较高,其低通畅率限制了其临床应用。本文介绍了小口径人工血管构建研究的国内外发展动态,包括人工血管支架的制备及修饰方法,细胞及细胞外微环境在人工血管构建中的作用,并对小口径人工血管构建面临的问题及研究方向进行了讨论与展望。

Progress and Prospect of Small-Diameter Vascular Grafts Research

There is a growing demand of vascular grafts for clinical treatment, the problem is also general, and especially the small-diameter vascular’s incidence rate of restenosis is high after implantation. Tissue engineering has been applied in the fabrication of vascular grafts, the bionic and tissue regeneration. Tissue engineered vascular graft have been developed as alternative to autografts, but the low patency limit their clinical application. In this review, we introduced the latest develepment of vascular grafts in both domestic and foreign research, including the fabrication and modification of artificial vascular scaffolds, the role of cellular and extracellular microenvironment in artificial vascular reconstruction. We also discussed the problems and prospects of the directions for the future research of tissue engineered vascular grafts.