新疆维吾尔自治区和田地区16例流行性脑脊髓膜炎患者的临床特征

目的了解新疆维吾尔自治区和田地区流行性脑脊髓膜炎的临床特征。 方法回顾性分析和田地区人民医院感染科2014年3月至2015年3月收治的16例流脑病例的临床资料。 结果流行性脑脊髓膜炎全年均有发病，4～6月为发病高峰季节，本研究入组对象中儿童病例11例，占68.75%，成人病例5例，占31.25%。普通型14例，暴发型2例，暴发型均为儿童。儿童患者与成人患者临床症状相比，儿童患者表现较重，儿童患者的降钙素原较成人患者显著升高（t =-2.668，P = 0.028）。 结论南疆地区流行性脑脊髓膜炎发病率较高，患者多为儿童，且临床症状较成人重，应早期诊断及时治疗，并加强适龄儿童脑膜炎球菌疫苗免疫工作。

Clinical analysis on 16 cases with epidemic cerebrospinal meningitis in Hotan,the Xinjiang Uygur Autonomous Region

ObjectiveTo investigate the clinical characteristics of epidemic cerebrospinal meningitis in Hotan, the Xinjiang Uygur Autonomous Region. MethodsThe data of 16 patients with epidemic cerebrospinal meningitis who were admitted to Hotan People’s Hospital from March 2014 to March 2015 were analyzed, retrospectively. Epidemic season, age, clinical characteristics, laboratory examination, treatment and prognosis of patients were analyzed, respectively. ResultsCerebrospinal meningitis mainly occurred on April to June. There were 11 children (68.75%) and 5 adults (31.25%) in this research. And 14 cases were with common type and 2 cases with fulminating type. Compared with the adult patients, the clinical manifestations of children were severe, and procalcitonin of children patients was higher (t =-2.668, P = 0.028). ConclusionsThere is a high occurrence of epidemic cerebrospinal meningitis in south of Xinjiang. The peak incidence of epidemic cerebrospinal meningitis occurs from April to June. Children were susceptible to epidemic cerebrospinal meningitis. The infection of children were more severe than adults. The immunization strategies are to enhance the rates of vaccine inoculation for epidemic cerebrospinal meningitis.