| 载有酮洛芬-乙基纤维素缓释固体分散体的海藻酸钙小珠的制备 |
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| 引用本文： | 陈 润,吴琼珠,平其能,杨金飞.载有酮洛芬-乙基纤维素缓释固体分散体的海藻酸钙小珠的制备[J].药学与临床研究,2010,18(3):222-225. |
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| 作者姓名： | 陈 润 吴琼珠 平其能 杨金飞 |
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| 作者单位： | 中国药科大学药剂学教研室,南京,210009 |
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| 摘 要： | 目的:制备酮洛芬-乙基纤维素固体分散体并将其包载于海藻酸钙小珠中,以期制备酮洛芬缓释微丸制剂.方法:采用一种新的溶剂萃取共沉淀法制备固体分散体,差示扫描量热法进行固体分散体物相分析;离子胶凝法将固体分散体包载进海藻酸钙小珠,扫描电子显微镜分析其形态,并考察其体外释药特性.结果:差示扫描量热分析证实药物以非晶型分散于载体中,较低的药物损失率和简便操作证明这种制备方法是可行的,固体分散体具有缓释效果,使用海藻酸钙小珠包载后,降低了在释放介质中的突释性.结论:本方法制备酮洛芬-乙基纤维素缓释固体分散体可行,海藻酸钙包载后降低了释放介质中的突释.
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| 关 键 词： | 缓释固体分散体 酮洛芬 乙基纤维素 海藻酸钙小珠 溶剂萃取共沉淀法 |
| 收稿时间： | 2010/3/15 0:00:00 |
| 修稿时间： | 2010/3/31 0:00:00 |
Preparation of Ketoprofen-Ethylcellulose Sustained Release Solid Dispersion encapsulated in Calcium Alginate Beads |
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| CHEN Run,WU Qiong-zhu,PING Qi-neng and YANG Jin-fei.Preparation of Ketoprofen-Ethylcellulose Sustained Release Solid Dispersion encapsulated in Calcium Alginate Beads[J].Pharmacertical and Clinical Research,2010,18(3):222-225. |
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| Authors: | CHEN Run WU Qiong-zhu PING Qi-neng and YANG Jin-fei |
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| Institution: | Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Objective: To prepare ketoprofen-ethylcellulose sustained release solid dispersion encapsulated in calcium alginate beads and to obtain ketoprofen sustained release beads. Methods: A new solvent extraction co-precipitation method was established to prepar |
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| Keywords: | Sustained release solid dispersion Ketoprofen Ethylcellulose Calcium alginate beads Solvent extraction co-precipitation method |
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