中西医结合治疗特应性皮炎的随机对照研究

目的:评价中西医结合治疗特应性皮炎(AD)的疗效。方法:采用多中心、随机对照平行设计,将146例AD患者随机分为研究组和对照组,分别用中西医结合(氯雷他定内服+糠酸莫咪松霜外用+中药内服)治疗和仅用西药治疗,疗程4周。治疗结束时行基于研究者总体评估(IGA)评分,于疗前及疗后第l、2,3、4周时访视湿疹面积与严重度指数(EASI)评分,随访治疗成功者12个月内的复发情况。结果:①治疗结束时研究组IGA评分0、1、2、3、4和5级者分别是5、18、32、13、4和1例,对照组分别是2、9、34、12、10和6例,差异有统计学意义,Z=-2.753,P=0.006。②随着治疗时间的延长,EASI评分逐渐降低(F=184.36,P=0.000),且研究组降低程度大于对照组(F=18.156,P=0.000)。③研究组和对照组治疗成功者12个月内的累计复发率分别是39.13%和81.82%,对照组复发的风险是研究组的3.118倍(HR=3.118),P=0.017。结论:中西结合治疗AD较单纯西药治疗具有较佳的改善症状体征、降低复发的效果。

Random control study on treating AD in the integrative medicine

Objective：To investigate the efficacy of integrative medicine on treating atopic dermatitis.Methods：146 AD patients were randomly divided into two groups.The control group was given Loratadine for oral use and Mometasone furoate for external use,while the treated group was given TCM for oral use more.After treatment,the IGA scores were undertaken.And the patients were selected to follow-up visit for 12 months based on the EASI scores.Results：After treatment,there were 5,18,32,13,4 and 1 cases of the IGA scores 0,1,2,3,4 and 5 respectively in the treated group,while in the control group were 2,9,34,12,10 and 6 cases respectively,with significant differences （Z=-2.753,P=0.006）.EASI scores stepped down along with the therapy time,and the reduction degree in the treated group was much greater than that in the control group （F=18.156,P=0.000）.The accumulative recurrence rates in 12 months in the treated group and the control group were 39.13% and 81.82% respectively.That in the treated group was 3.118 times as much as that in the control group （P=0.017）.Conclusion：The integrative medicine had more effective and lower recurrence rates than simple modern medicine on AD therapy.