| 慢性肾炎血清SOD、NO／NOS和T淋巴细胞亚群检测意义 |
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| 引用本文： | 张弘,刘建华,查冬青,朱芳,尹丽霞. 慢性肾炎血清SOD、NO／NOS和T淋巴细胞亚群检测意义[J]. 实用全科医学, 2008, 6(11): 1145-1146 |
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| 作者姓名： | 张弘 刘建华 查冬青 朱芳 尹丽霞 |
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| 作者单位： | 江苏省连云港市第一人民医院肾内科,222002 |
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| 摘 要： | 目的探讨慢性肾炎患者治疗前后血清SOD、NO／NOS和T淋巴细胞亚群水平的变化。方法分别应用放免法、化学法和单克隆抗体法对37例慢性肾炎患者进行了血清SOD、NO／NOS和T淋巴细胞亚群水平的检测，并与35名正常健康人作比较。结果慢性肾炎患者在治疗前血清NOS水平显著高于正常人组（P〈0．01）、而SOD、NO和CD4／CD8比值明显低于正常人组（P〈0．01），经治疗半年后血清SOD，NO／NOS和CD4／CD8与治疗前组比较差异有统计学意义（P〈0．05）。结论检测慢性肾炎患者血清SOD、NO／NOS和T淋巴细胞亚群水平对判断病情及其预后均具有一定的临床实用价值。
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| 关 键 词： | 慢性肾炎 超氧化物歧化酶(SOD) 一氧化氮(NO) 一氧化氮合酶(NOS) T-淋巴细胞亚群 |
Clinical Significance of the Changes of Serum Levels of SOD,NO/NOS and T-cell Subset in Patients with Chronic Nephritis |
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| ZHANG Hong,LIU Jian-hua,ZHA Dong-qing,et al.. Clinical Significance of the Changes of Serum Levels of SOD,NO/NOS and T-cell Subset in Patients with Chronic Nephritis[J]. Applied Journal Of General Practice, 2008, 6(11): 1145-1146 |
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| Authors: | ZHANG Hong LIU Jian-hua ZHA Dong-qing et al. |
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| Affiliation: | ZHANG Hong,LIU Jian-hua,ZHA Dong-qing,et al.Department of Nephrology,First People's Hospital of Lianyungang,Jiangsu 222002,China |
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| Abstract: | Objective To explore the changes in serum SOD,NO/NOS and T-Lymphocyte subsets before and after treatment in patients with chronic Nephritis.Methods The levels of serum SOD was detected with RIA,NO/NOS were detected with chemical methods and T-Lymphocyte subsets distribution type was detected with monoclonal antibody in 37 cases of chronic nephritis both before and after treatment and 35 controls.Results Before treatment,The levels of serum NOS were significantly higher than those in controls(P<0.01),while t... |
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| Keywords: | Chronic Nephritis Superoxide dismutase(SOD) Nitric oxide(NO) Nitric oxide synthases(NOS) T-lymphocyte subsets |
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