| 灯盏花素对脑缺血再灌注沙土鼠相关行为指标影响 |
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| 引用本文： | 刘云洁,李瑜,李淑红. 灯盏花素对脑缺血再灌注沙土鼠相关行为指标影响[J]. 青岛大学医学院学报, 2008, 44(4) |
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| 作者姓名： | 刘云洁 李瑜 李淑红 |
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| 作者单位： | 济宁医学院药学系化学教研室,山东,济宁,272000;青岛大学医学院附属医院麻醉科 |
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| 摘 要： | 目的 研究灯盏花素注射液对沙土鼠脑缺血再灌注后相关行为影响.方法 制备沙土鼠前脑缺血再灌注模型,脑缺血时间为10 min.将沙土鼠随机分为假手术组、对照组和灯盏花素组,每组8只动物,后两组再根据再灌注时间分为再灌注1、2、4、7 d等4个亚组.用开阔法观察沙土鼠脑缺血再灌注后行为学改变.实验期间始终将沙土鼠脑温控制在(37.2±0.2)℃.结果 沙土鼠脑缺血再灌注后1、2、4和7 d,对照组相关行为学指标评分明显高于假手术组,而灯盏花素组沙土鼠行为学评分尽管高于假手术组,但明显低于对照组.结论 灯盏花素可减轻脑缺血再灌注对沙土鼠相关行为学指标的影响,减轻沙土鼠脑缺血再灌注损伤.
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| 关 键 词： | 灯盏花素 再灌注损伤 行为 |
EFFECT OF BREVISCAPINE ON THE ETHOLOGICAL INDEX AFTER CEREBRAL ISCHEMIA/REPERFUSION IN GERBILS |
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| LIU YUN-JIE,LI YU,LI SHU-HONG. EFFECT OF BREVISCAPINE ON THE ETHOLOGICAL INDEX AFTER CEREBRAL ISCHEMIA/REPERFUSION IN GERBILS[J]. Acta Academiae Medicinae Qingdao Universitatis, 2008, 44(4) |
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| Authors: | LIU YUN-JIE LI YU LI SHU-HONG |
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| Abstract: | Objective To investigate the effect of breviscapine on the ethological index after cerebral ischemia/reperfusion in gerbils. Methods A cerebral-ischemia-reperfusion model of gerbils was established,ischemia time being 10 minutes.Gerbils were randomised to sham-group,control group and breviscapine group.They were further divided into four subgroups,eight in each group.Reperfusion was carried out in the latter two groups,which lasted for 1,2,4,and 7 d,respectively.The ethological index of gerbils was counted ... |
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| Keywords: | Breriscapine Reperfusion injury Behavior |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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