| 尖锐湿疣皮损中的微卫星DNA不稳定性 |
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| 引用本文： | 袁伟,陈晓红,瓦庆彪,郑庭铭,张信江. 尖锐湿疣皮损中的微卫星DNA不稳定性[J]. 临床皮肤科杂志, 2004, 33(11): 653-655 |
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| 作者姓名： | 袁伟 陈晓红 瓦庆彪 郑庭铭 张信江 |
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| 作者单位： | 遵义医学院附属医院皮肤科,贵州,遵义,563003;遵义医学院附属医院皮肤科,贵州,遵义,563003;遵义医学院附属医院皮肤科,贵州,遵义,563003;遵义医学院附属医院皮肤科,贵州,遵义,563003;遵义医学院附属医院皮肤科,贵州,遵义,563003 |
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| 基金项目： | 中华医学会皮肤科学会科研基金资助项目(诺华公司资助,200130)贵州省省长基金资助项目(C-197) |
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| 摘 要： | 目的：探讨微卫星不稳定性在尖锐湿疣及其癌变中的作用及意义。方法：采用聚合酶链-单链构象多态性分析(PCR-SSCP)检测28例尖锐湿疣皮损中的微卫星DNA改变。结果：28例尖锐湿疣皮损中8例存在微卫星不稳定性。而且其主要出现在尖锐湿疣癌变中,未发现杂合性丢失。结论：尖锐湿疣及其癌变与微卫星不稳定性有关,临床上通过对尖锐湿疣患者微卫星不稳定性的检测,有可能对尖锐湿疣癌变作出可能性预测及早期诊断,为发现癌变高危人群提供新的依据。
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| 关 键 词： | 尖锐湿疣 微卫星DNA 微卫星不稳定性 |
| 文章编号： | 1000-4963(2004)11-0653-03 |
| 修稿时间： | 2004-01-27 |
Detection of microsatellite instability in the lesions of condyloma acuminatum |
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| YUAN Wei,CHEN Xiao-hong,WA Qing-biao,ZHENG Ting-ming,ZHANG Xin-jiang,. Detection of microsatellite instability in the lesions of condyloma acuminatum[J]. Journal of Clinical Dermatology, 2004, 33(11): 653-655 |
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| Authors: | YUAN Wei CHEN Xiao-hong WA Qing-biao ZHENG Ting-ming ZHANG Xin-jiang |
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| Abstract: | Objective: To investigate the significance of microsatellite instability (MSI) in the lesions of condyloma acuminatum (CA) and its role in canceration. Methods: Both MSI and loss of heterozygosity (LOH) were detected in 28 CA samples by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). Results: MSI was observed in 8 patients with CA, whereas no LOH was found. The positive rates of MSI increased significantly in CA patients with anaplasia or canceration. Conclusion: MSI might be related to CA and its canceration. Detection of microsatellite instability in the lesions of CA might be used to find high risk group of canceration. |
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| Keywords: | condyloma acuminatum microsatellite DNA microsatellite instability |
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