Analysis of meiotic recombination events near a recombination hotspot in the yeast Saccharomyces cerevisiae |
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| Authors: | Michael A. White Thomas D. Petes |
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| Affiliation: | (1) Department of Biology, University of North Carolina, 27599-3280 Chapel Hill, NC, USA;(2) Present address: Cold Spring Harbor Laboratory, P.O. Box, 100, 11724 Cold Spring Harbor, NY, USA |
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| Abstract: | The region of yeast chromosome III between the HIS4 and LEU2 genes has an unusually high frequency of meiotic recombination. In order to determine the pattern of cross-over and gene conversion events, we constructed a strain with a number of heterozygous markers in this 25-kb interval. We found that very high levels of reombination are localized to regions of DNA near HIS4. In addition, analysis of the patterns of co-conversion of adjacent markers suggests that there is more than one initiation site contributing to recombination of HIS4. |
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| Keywords: | Recombination Yeast Cross-over Gene conversion |
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