| 多巴胺受体D2基因TaqI位点多态性与帕金森病的关系 |
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| 引用本文： | 李伟,孙茂民,林雪霞,姜炳正,夏春林. 多巴胺受体D2基因TaqI位点多态性与帕金森病的关系[J]. 苏州大学学报(自然科学版), 2009, 29(2): 303-306 |
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| 作者姓名： | 李伟 孙茂民 林雪霞 姜炳正 夏春林 |
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| 作者单位： | 李伟,LI Wei(河北省邢台市第一医院,神经内科,河北邢台,054001;苏州大学,衰老与神经疾病实验室及博习临床解剖学研究所,江苏苏州,215123);孙茂民,夏春林,SUN Mao-min,XIA Chun-lin(苏州大学,衰老与神经疾病实验室及博习临床解剖学研究所,江苏苏州,215123);林雪霞,姜炳正,LIN Xue-xia,JIANG Bing-zheng(邢台医学高等专科学校,基础部,河北邢台,054001) |
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| 摘 要： | 目的探讨多巴胺受体D2（DRD2）基因TaqI酶切位点多态性与帕金森病（Parkinson’s disease,PD）遗传易感性的关系。方法选择PD患者166例和正常对照170人,利用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术分析了TaqI位点A1/A1、A1/A2、A2/A2、B1/B1、B1/B2、B2/B2基因型在PD患者与正常对照组之间的分布情况。结果DRD2基因TaqI酶切位点在总体PD患者和总体对照组之间的分布差异无统计学意义（P〉0.05）;根据发病年龄和性别分组后,不管是早发还是晚发PD患者,无论男性还是女性,PD组和对照组的基因型和等位基因频率的差异均无统计学意义（均P〉0.05）。结论DRD2基因TaqI多态性与PD的遗传易感性无关。
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| 关 键 词： | 帕金森病 多巴胺D2受体 基因 多态性 |
The Relationship Between Genetric Polymorphism of Dopamine Receptor-D2 Gene and Parkinson's Disease in Chinese |
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| LI Wei,SUN Mao-min,LIN Xue-xia,JIANG Bing-zheng,XIA Chun-lin. The Relationship Between Genetric Polymorphism of Dopamine Receptor-D2 Gene and Parkinson's Disease in Chinese[J]. Suzhou University Journal of Medical Science, 2009, 29(2): 303-306 |
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| Authors: | LI Wei SUN Mao-min LIN Xue-xia JIANG Bing-zheng XIA Chun-lin |
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| Affiliation: | LI Wei, SUN Mao-min, LIN Xue-xia, JIANG Bing-zheng, XIA Chun-lin(1.Dept of Neurology,the First Hospital of Xingtai,Hebei Xingtai 054001 ,China; 2.Lab of Aging and Nervous Disease ＆ Boxi Institute of Clinical Anatomy,Soochow University,Jiangsu Suzhou 215123, China; 3.Dept of Basical,High Medical Training School of Xingtai, Hebei Xingtai 054001, China) |
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| Abstract: | Objective To detect the polymorphism of dopamine receptor-D2 （DRD2） gene TaqI site and suseeptility of Parkinson＇s disease（PD）. Methods One hundred and sixty-six patients with PD and 170 normal controls were selected as the experimental groups. PCR-RFLP was used to detect the distribution of TaqI alleles A1/A1, A1/A2, A2/A2; B1/B1, B1/B2, B2/B2 genotypes in the selected PD patients and control groups. Results There was no significant difference between the PD patients group and control group in allelic and genotypic distributions of the DRD2 gene TaqI loci. There was no clear different in the frequencies of alleles and genotypes both in the patient and control groups regardl whether early or late outbreak PD and gender （P〉0.05）. Conclusion The results in present study support the hypothesis that susceptibility to PD is associated with the DRD2 gene polymorphisms ined in our population. |
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| Keywords: | Parkinson＇s disease dopamine D2 receptor genes polymorphism ess of don＇t exam- |
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