Subcutaneous cryptococcosis due to Cryptococcus diffluens in a patient with sporotrichoid lesions case report, features of the case isolate and in vitro antifungal susceptibilities. |
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Authors: | A Serda Kantarcio?lu Teun Boekhout G Sybren De Hoog Bart Theelen Ayhan Yücel Tuba R Ekmekci Bettina C Fries Reiko Ikeda Adem Koslu Kemal Altas |
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Institution: | Cerrahpasa Medical Faculty, Department of Microbiology and Clinical Microbiology, Deep Mycosis Laboratory, Istanbul University, Istanbul,Turkey. s.kantarcioglu@superonline.com |
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Abstract: | Environmental fungi, in particular primary pathogens and Cryptococcus spp. can be responsible for skin lesions mimicking sporotrichosis. In this paper, we report a case of subcutaneous cryptococcosis in an apparently healthy, young male patient due to a non-C. neoformans Cryptococcus species, C. diffluens. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. This species shares several phenotypic traits with C. neoformans, and, therefore, decisive diagnosis should be based on biopsy and culturing results followed by molecular identification. |
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