| pH敏感性P(AM-AA-co-C8PhEO10Ac)水凝胶溶胀动力学及其对茶碱的控释 |
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| 引用本文： | 王芳平,张珺瑛,牟琥珀,李晚霞,王其召,杜新贞. pH敏感性P(AM-AA-co-C8PhEO10Ac)水凝胶溶胀动力学及其对茶碱的控释[J]. 医学教育探索, 2013, 26(2) |
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| 作者姓名： | 王芳平 张珺瑛 牟琥珀 李晚霞 王其召 杜新贞 |
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| 作者单位： | 西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730070;西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730071;西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730072;西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730073;西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730074;西北师范大学化学化工学院，甘肃省生物电化学与环境分析重点实验室，兰州 730075 |
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| 基金项目： | 国家自然科学基金 (21065010，51262028)资助项目 |
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| 摘 要： | 以丙烯酰胺(AM)、丙烯酸(AA)和丙烯酸辛基酚聚氧乙烯醚酯(C8PhEO10Ac)为单体，采用自由基交联共聚法合成了具有pH敏感性的P(AM-AA-co-C8PhEO10Ac)水凝胶。研究了pH、单体配比对凝胶溶胀性能、溶胀动力学和退溶胀动力学的影响。初步探讨了模拟胃液(pH=1.4)、肠液(pH=7.4)中水凝胶对茶碱的控释情况。结果表明:凝胶具有高溶胀、退溶胀速率和良好的pH敏感性等特征；水凝胶的扩散行为在pH=7.4的缓冲溶液中为非Fickian扩散模式；载药凝胶在模拟肠液中对药物的累积释放率明显大于胃液中的累积释放率，其中n(C8PhEO10Ac)∶n(AM)∶n(AA)为1∶20∶30的载药水凝胶对茶碱的累积释放率最大。
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| 关 键 词： | 水凝胶； pH敏感； 溶胀动力学； 控制释放 |
Swelling Kinetics and Theophylline Controlled-Release Properties of pH-Sensitive P(AM-AA-co-C8PhEO10Ac) Hydrogel |
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| WANG Fang-ping,ZHANG Jun-ying,MU Hu-po,LI Wan-xi,WANG Qi-zhao and DU Xin-zhen. Swelling Kinetics and Theophylline Controlled-Release Properties of pH-Sensitive P(AM-AA-co-C8PhEO10Ac) Hydrogel[J]. Researches in Medical Education, 2013, 26(2) |
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| Authors: | WANG Fang-ping ZHANG Jun-ying MU Hu-po LI Wan-xi WANG Qi-zhao DU Xin-zhen |
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| Affiliation: | Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China;Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730071, China;Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730072, China;Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730073, China;Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730074, China;Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730075, China |
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| Abstract: | |
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| Keywords: | hydrogel pH-sensitivity swelling kinetics controlled release |
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