| 愈肠宁胶囊中苦参提取物的生物碱类成分指纹图谱分析 |
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| 引用本文： | 向孙敏,韩丽,刘李梅,张超,王莹,谢兴亮. 愈肠宁胶囊中苦参提取物的生物碱类成分指纹图谱分析[J]. 中国实验方剂学杂志, 2013, 19(14): 13-16 |
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| 作者姓名： | 向孙敏 韩丽 刘李梅 张超 王莹 谢兴亮 |
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| 作者单位： | 1. 成都中医药大学,中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都611137
2. 成都医学院药学院,成都,610083 |
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| 基金项目： | 国家科技重大专项"十二五"重大新药创制项目(2012ZX09102201-103) |
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| 摘 要： | 目的:建立愈肠宁胶囊中苦参提取物生物碱类成分的HPLC指纹图谱的检测方法.方法:采用Kromasil NH2氨基柱(4.6 mm×250 mm,5μm),流动相乙腈-乙醇(8∶1)-3％磷酸水梯度洗脱,流速0.8 min· mL-1,检测波长220 nm,对10批苦参提取物进行HPLC指纹图谱检测,采用“中药色谱指纹图谱评价系统2004年版”进行评价.结果:苦参提取物采用氨基柱各峰分离效果好,确定了15个共有峰,并对其中4个色谱峰进行了指认,10批提取物的相似度均＞0.9,提取物与药材指纹图谱间存在相关性.结论:该方法精密度、重复性、稳定性较好,为苦参提取物的质量控制提供了一种检测方法.
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| 关 键 词： | 苦参 提取物 生物碱 指纹图谱 |
| 收稿时间： | 2012-12-28 |
Fingerprint Analysis of Alkaloids from Extract of Sophora flavescens in Yuchangning Capsules |
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| XIANG Sun-min,HAN Li,LIU Li-mei,ZHANG Chao,WANG Ying and XIE Xing-liang. Fingerprint Analysis of Alkaloids from Extract of Sophora flavescens in Yuchangning Capsules[J]. China Journal of Experimental Traditional Medical Formulae, 2013, 19(14): 13-16 |
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| Authors: | XIANG Sun-min HAN Li LIU Li-mei ZHANG Chao WANG Ying XIE Xing-liang |
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| Affiliation: | State Key Laboratory Breeding Base of System Research and Development Utilization of Chinese Materia Medica Resources, Chengdou University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of System Research and Development Utilization of Chinese Materia Medica Resources, Chengdou University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of System Research and Development Utilization of Chinese Materia Medica Resources, Chengdou University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of System Research and Development Utilization of Chinese Materia Medica Resources, Chengdou University of Traditional Chinese Medicine, Chengdu 611137, China;State Key Laboratory Breeding Base of System Research and Development Utilization of Chinese Materia Medica Resources, Chengdou University of Traditional Chinese Medicine, Chengdu 611137, China;Pharmaceutical College of Chengdu Medical College, Chengdu 610083, China |
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| Abstract: | |
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| Keywords: | Sophora flavescens extract alkaloids fingerprint |
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