人类垂体腺瘤中的基因突变

由于人类垂体腺瘤是单克隆细胞起源，故提示基因突变在肿瘤生成中发挥着重要作用。目前发现包括生长激素腺瘤癌基因gsp的表达，癌基因p53表达异常，MEN-1缺失和P16的高甲基化等，在垂体腺瘤发生发展和侵袭性生长中发挥作用

Gene mutation in pituitary adenomas of human

The single colonel composition of pituitary adenomas of human attests to the molecular basis of pituitary tumorigenesis. This review offers a specific overview of the involvement of alternation of tumor oncogenes and tumor suppressor genes (TSGs) in the pathogenesis of human pituitary adenomas. Mutations of gsp and H ras oncogenes genes and amplification of PKC have been identified in pituitary adenomas. Especially the mutation of gsp has been detected in 40% human GH secreting pituitary adenomas. The role of TSGs(tumor suppressor genes) including MEN 1, p53, Rb and p16 in pituitary adenoma formation and progression has yet be observed. Providing evidence proves that activation of oncogenes and inactivation of tumor suppressor genes seem to be at least one mechanism by which human pituitary adenomas origin and progress.