Kynurenic acid inhibition of an experimental epileptogenic focus in the rat hippocampus

Kynurenic acid introduced in an epileptogenic focus through an electrochemotrode before the creation of the focus was found to reduce the intensity of epileptiform discharges between seizures and of electrographic correlates of seizures on the electroencephalogram. Administration of kynurenic acid led to the appearance of a slow Θ-rhythm dominating in all the leads. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 5, pp. 521–522, May, 1995 Presented by S. N. Golikov, Member of the Russian Academy of Medical Sciences