音乐疗法辅助治疗慢性精神分裂症的Meta分析

目的评价音乐疗法辅助治疗慢性精神分裂症的疗效。方法采用固定效应模型或随机效应模型对包括603例慢性精神分裂症患者的11篇文献进行Meta分析。结果综合6个随机对照试验结果发现,试验组(音乐疗法加药物组)和对照组(单用药物组)的疗效差别有统计学意义,对照组阴性症状评定量表(SANS)及简明精神病量表(BPRS)总分均比试验组高(d=0.68,95%CI:0.46～0.90;d=0.44,95%CI:0.06～0.82);综合5个自身对照试验结果发现,试验前后的疗效差别有统计学意义,试验前SANS及BPRS总分比试验后高(d=1.17,95%CI:0.02～2.32;d=2.05,95%CI:0.28～3.82)。结论音乐疗法辅助治疗慢性精神分裂症近期疗效较好,其远期疗效有待进一步探讨。

Meta-analysis of assisted music therapy for chronic schizophrenia

OBJECTIVE: To evaluate the effect of assisted music therapy for chronic schizophrenia. METHODS: 11 articles including 603 chronic schizophrenia patients were meta-analyzed using fixed effect model or random effect model. RESULTS: 6 randomized controlled trials were synthesized, showing that the difference was significant in statistics between experimental group (patients with music and drugs therapy) and control group (patients with drugs therapy only). Both the scores of SANS and BPRS for the control group were higher than those for the experimental group (SANS, d = 0.68; 95%CI: 0.46-0.90 and BPRS, d = 0.44; 95%CI: 0.06-0.82). In addition, the scores of both SANS and BPRS for the pre-test were higher than those for the post-test (SANS, d = 1.17; 95%CI: 0.02-2.32 and BPRS, d = 2.05; 95%CI: 0.28-3.82). CONCLUSION: The short-term effect of assisted music therapy is positive for chronic schizophrenia, but the long-term effect is still to be further studied.