| 鳖血提取物对小鼠免疫功能正向调节作用的研究 |
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| 引用本文： | 王颖,张惠珍,王树军,张勇,沈天伟,陈广洁,葛海良. 鳖血提取物对小鼠免疫功能正向调节作用的研究[J]. 细胞与分子免疫学杂志, 2004, 20(1): 123-125 |
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| 作者姓名： | 王颖 张惠珍 王树军 张勇 沈天伟 陈广洁 葛海良 |
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| 作者单位： | 上海第二医科大学,上海市免疫学研究所,上海,200025 |
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| 摘 要： | 目的 :研究鳖血提取物对小鼠的免疫调节功能。方法 :采用环磷酰胺为免疫抑制剂 ,获得免疫功能低下的小鼠动物模型。比较鳖血提取物作用前后 ,小鼠T细胞亚群的数量、NK细胞的杀伤功能 ,淋巴细胞的增殖功能以及细胞因子水平的变化。结果 :鳖血提取物对免疫功能低下小鼠的CD4 T细胞在外周血中的比例、NK细胞的杀伤活性、淋巴细胞的增殖功能 ,均具有正向调节作用 (P <0 .0 5 ) ,并呈剂量依赖性 ;能提高淋巴细胞分泌IFN γ的能力。结论 :鳖血提取物具有正向调节小鼠免疫功能的能力
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| 关 键 词： | 鳖血 免疫功能 正向调节 |
| 文章编号： | 1007-8738(2004)01-0123-03 |
| 修稿时间： | 2003-04-28 |
Immunological up-regulation of cyclophosphamide-treated mice by turtle blood extract |
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| WANG Ying,ZHANG Hui-zhen,WANG Shu-jun,ZHANG Yong,Shen Tian-wei,CHEN Guang-jie,GE Hai-liang. Immunological up-regulation of cyclophosphamide-treated mice by turtle blood extract[J]. Chinese journal of cellular and molecular immunology, 2004, 20(1): 123-125 |
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| Authors: | WANG Ying ZHANG Hui-zhen WANG Shu-jun ZHANG Yong Shen Tian-wei CHEN Guang-jie GE Hai-liang |
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| Affiliation: | Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China. ywang@sibs.ac.cn |
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| Abstract: | AIM: To explore the effect of turtle blood extract on murine immune system. METHODS: We compared the ratio of CD4(+) helper T cells and CD8(+) T cells, NK cell activity, lymphocyte proliferation stimulated by mitogen and capability of cytokine secretion of cyclosphophamide-treated mice with or without treatment of turtle blood extract. RESULTS: Turtle blood extract-treated mice displayed increased CD4(+) helper T cell population, stronger cytotoxicity of NK cells and enhanced of ConA-induced lymphocyte proliferation. In addition, the capacity of IFN-gamma secretion was dramatically up-regulated in turtle blood extract-treated mice group. CONCLUSION: Turtle blood extract can upregulate the immune function of cyclosphophamide-treated mouse. |
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| Keywords: | turtle blood immune function up-regulation |
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