血脂达标后长期降脂治疗方法的探讨

目的 :观察隔晚服用瑞舒伐他汀10 mg的疗效,探讨血脂达标后的后续治疗方案。方法:选取我院2008年5月至2010年5月,LDL<2.59 mmol/L的75岁以下稳定心绞痛患者共100例,常规服用瑞舒伐他汀10 mg/晚,1个月后随机分为两组:常规组(瑞舒伐他汀10 mg/晚)和试验组(瑞舒伐他汀10 mg/隔晚),随访6个月,观察患者的依从性、LDL的变化。结果:共有16例患者退出,实际入选84例,其中常规组41例,试验组43例,基线LDL水平(2.40±0.17)mmol/L。服用瑞舒伐他汀1个月后,LDL平均降低了(0.33±0.22)mmol/L,降低了13%。6个月,常规组降低了(0.51±0.19)mmol/L,降低了21.3%,治疗组(0.48±0.20)mmol/L,降低了19.6%,两组之间差异无统计学意义。结论:血脂达标后,隔晚服用常规剂量的瑞舒伐他汀,可以有效地降低LDL水平,增加患者依从性。

To study the lowing-lipid therapy for who had achieved the low-density lipoprotein cholesterol goal

Objective:To observe the efficacy of 10mg rosuvastatin alternate night,and discusses the subsequent therapy for who had attained the LDL goal.Methods: 100 stable angina cases were elected whose LDL level lower than 2.59 mmol/L,and age lower than 75 years old during May 2008 to May 2010.After a month washout period(10mg rosuvastin per night),random divided into two groups,routine group who has 10mg rosuvastatin every night,and trial group instead 10mg rosuvastatin every other night,followed up half a year,to observe the change of compliance,and the level of LDL.Results: 84 patients finished while 16 case removed,including 41 patients in routine group and 43 in trial group,the baseline level of LDL was(2.40±0.17)mmol/L.After A month washout period,the LDL level decreased(0.33±0.22)mmol/L,about 13 percent.After half a year,(0.51±0.19)mmol/L was decreases in routine group,about 21.3 percent,while other group was(0.48±0.20)mmol/L,about 19.6 percent,there are on statistic difference.Conclusion: For those who had attained LDL goal has 10mg rosuvastatin alternate night can decrease the LDL level effetely,and increase the patient compliance.