Microspectrofluorometric quantitation of autofluorescent lipopigment in the human sympathetic ganglia期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Microspectrofluorometric quantitation of autofluorescent lipopigment in the human sympathetic ganglia

Authors:	J Koistinaho M Sorvaniemi H Alho A Hervonen

Affiliation:	1. Department of Biomedical Sciences and Section of Gerontology, University of Tampere, Box 607, SF-33101 Tampere Finland;2. Department of Public Health, University of Tampere, Box 607, SF-33101 Tampere Finland;1. Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, 100853, China;2. Medical School of Chinese PLA, Beijing, China;3. Department of General Surgery, The 983rd Hospital of Joint Logistic Support Force of PLA, Tianjin, 300142, China;1. Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel;2. Faculty of Medicine, Tel-Aviv University, Israel;3. Department of Geriatric Medicine C, Sheba Medical Center, Tel Hashomer, Israel;4. Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, UK;5. Heart Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel;6. Davidai Arrhythmia Center, Sheba Medical Center, Tel Hashomer, Israel;7. Chief Physician''s Office, Clalit Health Services Tel Aviv, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel;8. Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel

Abstract:	The age-related changes in lipopigment autofluorescence were studied by microspectrofluorometry in three different types of human neurons: the sympathetic neurons of the stellate and superior mesenteric ganglion and pyramidal neurons of the frontal cortex. The age-related increase in lipopigment autofluorescence was more rapid in stellate ganglion but similar linear increases were found also in superior mesenteric ganglion and frontal cortex. There was an age-related shift in the autofluorescence from yellow to orange in the ganglia. This may be due to the accumulation of neuromelanin in noradrenergic neurons. Lipopigments were identified in sympathetic neurons at the age of 4 months and all neurons carried pigment granules after the age of 64 years. It is concluded that lipopigment autofluorescence is a useful marker for cellular ageing in both the peripheral and the central nervous system.

Keywords:
本文献已被 ScienceDirect 等数据库收录！

设为首页 | 免责声明 | 关于勤云 | 加入收藏