| 国产那格列奈片对2型糖尿病疗效的临床评价 |
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| 引用本文： | 夏礼斌,陆美琴,张斌华,张安素,陈月平,华强,冒国光.国产那格列奈片对2型糖尿病疗效的临床评价[J].中国临床药理学与治疗学,2004,9(8):932-934. |
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| 作者姓名： | 夏礼斌 陆美琴 张斌华 张安素 陈月平 华强 冒国光 |
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| 作者单位： | 1. 皖南医学院弋矶山医院内分泌科,芜湖,241001,安徽
2. 国家药品临床研究基地,芜湖,241001,安徽 |
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| 摘 要： | 目的：评价国产那格列奈片治疗2型糖尿病的疗效。方法：46例2型糖尿病患者随机分入那格列奈组和瑞格列奈组，以瑞格列奈作阳性对照，检测空腹血糖及糖化血红蛋白(HbA1C)。结果：两组治疗后空腹指尖及静脉血糖、糖化血红蛋白均有所下降，治疗8周后瑞格列奈组空腹指尖血糖改善值优于那格列奈组。结论：那格列奈片能改善2型糖尿病患者的糖代谢，是一种安全有效的降糖药物。
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| 关 键 词： | 那格列奈 瑞格列奈 2型糖尿病 空腹血糖 糖化血红蛋白 |
| 文章编号： | 1009-2501(2004)08-0932-03 |
| 修稿时间： | 2004年7月22日 |
Clinical evaluation on efficacy of domestic nateglinide tablet in patients with type 2 diabetes mellitus |
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| XIA Li-Bin,LU Mei-Qin,ZHANG Bin-Hua,ZHANG An-Su,CHEN Yue-Ping,HUA Qiang,MAO Guo-Guang.Clinical evaluation on efficacy of domestic nateglinide tablet in patients with type 2 diabetes mellitus[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2004,9(8):932-934. |
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| Authors: | XIA Li-Bin LU Mei-Qin ZHANG Bin-Hua ZHANG An-Su CHEN Yue-Ping HUA Qiang MAO Guo-Guang |
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| Institution: | XIA Li-Bin,LU Mei-Qin,ZHANG Bin-Hua,ZHANG An-Su,CHEN Yue-Ping,HUA Qiang,MAO Guo-Guang1 Department of Endocrinology,1National Drug Clinical Research Base,Yijishan Hospital,Wannan Medical College,Wuhu 241001,Anhui,China |
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| Abstract: | AIM: To evaluate the efficacy of domestic nateglinide tablet with the treatment of patients with type 2 diabetes mellitus (T 2DM). METHODS: Forty-six patients of T 2DM were included in this study. The twenty-three patients in nateglinide group took nateglinide tablet, and another twenty-three patients in the repaglinide group took repaglinide tablet. The changes of both fasting blood glucose and hemoglobin A 1C(HbA 1C) levels were assayed. RESULTS: After the treatment of 12 weeks, the levels of fasting blood glucose and HbA 1C decreased significantly (P< 0.01). After 8th weeks, the levels of fasting blood glucose of repaglinide group on finger-tip decreased significantly than those of the nateglinide group. CONCLUSION: Domestic nateglinide, as an effective and safe agent, can improve the glycometabolism in treating T 2DM. |
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| Keywords: | nateglinide tablet repaglinide tablet hemoglobin A 1C type 2 diabetes mellitus fasting blood glucose |
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