Transient increase of brain derived neurotrophic factor mRNA expression in substantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway |
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| Authors: | Aliaga E Cárcamo C Abarca J Tapia-Arancibia L Bustos G |
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| Institution: | Laboratorio de Farmacología-Bioquímica, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago. |
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| Abstract: | By using non-isostopic in situ hybridization we have demonstrated a transient increase of BDNF mRNA in the lateral subregion of the substantia nigra pars reticulata 1 week after intrastriatal application of 6-OH-DA. These changes correlate with a partial reduction of dopamine (DA) content in the striatum but with a normal tyrosine hydroxylase immunoreactivity in substantia nigra pars compacta. Our data suggest that non-DA, BDNF expressing cells in substantia nigra pars reticulata may play a role in neuronal protection after partial lesions of the DA nigrostriatal pathway. |
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