食管鳞癌和宫颈鳞癌组织中p53蛋白过度表达及其与放疗效果的关系(英文)

目的:探讨p53蛋白过度表达与食管鳞癌和宫颈鳞癌临床放射敏感性的关系。方法:免疫组化法研究52例食管鳞癌和宫颈鳞癌标本中p53蛋白过度表达状况,并分析其与近期放疗效果的关系。结果:p53蛋白在食管鳞癌和宫颈鳞癌中的过度表达分别为52.38％和35.48％,过度表达率在高分化鳞癌中较中低分化者低(P<0.05),与病期无关(P>0.05)。在宫颈鳞癌,p53蛋白过度表达者放疗效果较差(P<0.05),食管鳞癌p53蛋白过度表达与放疗效果间无明显关系(P>0.05)。结论:p53蛋白过度表达与食管鳞癌和宫颈鳞癌放射敏感性有关,但不是惟一影响因素。

Overexpression of p53 Gene in Esophageal and Cer-vical Cancer and the Relationship with Radiothera-py Effects

Objective :To investigate the relationship between p53 -protein overexpression in esophageal and cervical squamous cell cancer and their clinical radiosensitivity. Methods: The immuno-histochemical assays were done for 52 cases with esophageal and cervical squamous cell cancer. The relationship between the assay results and short-term radiotherapy was investigated. Results: p53 overexpression was 52. 38% and 35. 48% respectively, in esophageal cancer and cervical cancer; p53 over-expression in high differentiated squamous cell cancer was lower than those in moderate and poor differentiated cases(P<0. 05). There was no relationship between p53 overexpression and stages(P> 0. 05). In the cases of cervical cancer, p53 overexpression had the less short-term effect(P< 0. 05), and In esophageal cancers, there was no relationship with radiotherapy effect(P>0. 05). Conclusion:This study suggests that y53 gene lias the certain relationship with tumor radiosensitivity.