银曲胶囊对高脂血症大鼠血脂的影响

目的：观察银曲胶囊对实验性高脂血症大鼠血脂水平的影响。方法：大鼠用高脂饲料喂养2周以造成脂代谢紊乱模型,并根据体重或血清中总胆固醇水平随机分为模型组、血脂康组和银曲胶囊大、中、小3个剂量组（0.5、1.0、2.0g/kg）。采用预防和治疗给药,通过测定大鼠血清中总胆固醇、甘油三酯等水平,观察银曲胶囊对实验性大鼠血脂的影响。结果：在预防和治疗实验中,银曲胶囊大、中、小3个剂量组血清中总胆固醇、甘油三酯、低密度脂蛋白、极低密度脂蛋白等水平与模型组比较均有一定程度降低,高密度脂蛋白水平略升高（P〈0.05或P〈0.01）。结论：银曲胶囊对实验性高脂血症大鼠有一定的防治作用。

Effects of Yinqu Capsule on blood lipid in rats with experimental hyperlipidemia

AIM :To observe the effects of Yinqu Capsule on blood lipid in rats with experimental hyperlipidemia.METHODS :Rats were fed with fatty forage for two weeks to make the model of hyperlipidemia.The rats were randomly divided into five groups:model group,Xuezhikang group and three dosages of Yinqu Capsule groups.The drugs were administered for two weeks consecutively.The levels of T-CHOL,TG,LDL-C and VLDL-C in serum of rats were detected to observe the preventive and therapeutical effects of Yinqu Capsule.RESULTS :Compared with control group,the levels of T-CHOL,TG,LDL-C,VLDL-C and T-CHOL/HDL-C of Yinqu Capsule groups were significantly decreased and the content of HDL-C was slightly increased(P < 0.05 or P < 0.01).CONCLUSION :Yinqu Capsule could modulate blood lipid of hyperlipidemia rats to a certain extent.