| 骨髓基质细胞基因表达的研究进展 |
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| 引用本文： | 韩冰,付小兵,孙晓庆.骨髓基质细胞基因表达的研究进展[J].中国修复重建外科杂志,2005,19(2):153-158. |
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| 作者姓名： | 韩冰 付小兵 孙晓庆 |
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| 作者单位： | 1. 解放军第148医院
2. 解放军总医院304,临床部全军创伤修复重点实验室,北京,100037 |
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| 基金项目： | 国家重点基础研究发展规划资助项目 (G1 9990 542 0 4 )，国家自然科学基金重点资助项目 (30 2 30 370 )~~ |
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| 摘 要： | 目的介绍骨髓基质细胞(marrow stromal cells，MSCs)基因表达与其生物学特性、诱导分化、基因治疗、造血调控和创伤修复中的炎症反应等方面的研究进展。方法查阅国内外近年有关文献，并做综合分析。结果MSCs不仅能在不同的条件下表达中胚层、内胚层和外胚层的特异性基因，而且能稳定地表达转导的外源基因，并且对造血系统有支持作用，也参加创伤修复过程中的炎症反应。结论MSCs是一种具有自我更新和多向分化潜能的干细胞，且体外易于扩增，是一种理想的细胞治疗和基因治疗的靶细胞。
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| 关 键 词： | 骨髓基质细胞 创伤修复 基因表达 炎症反应 基因治疗 研究进展 内胚层 外源基因 自我更新 干细胞 |
| 修稿时间： | 2003年9月15日 |
ADVANCES IN GENE EXPRESSION OF BONE MARROW STROMAL CELLS |
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| HAN Bing,FU Xiaobing,SUN Xiaoqing. Key Research Laboratory of Wound Repair of PLA,th Clinical.ADVANCES IN GENE EXPRESSION OF BONE MARROW STROMAL CELLS[J].Chinese Journal of Reparative and Reconstructive Surgery,2005,19(2):153-158. |
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| Authors: | HAN Bing FU Xiaobing SUN Xiaoqing Key Research Laboratory of Wound Repair of PLA th Clinical |
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| Institution: | Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing, 100037, PR China. |
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| Abstract: | Objective To review the advances in gene expression of marrow stromal cells(MSCs) in biological characteristic, differentiation, gene therapy, supporting hematopoiesis, inflammation reaction in wound repair. Methods The related articles in recent years were extensively reviewed. Results MSCs can express not only specific mRNA of mesodermal cells but also that of endodermal and ectodermal cell types on various differentiation conditions. When transfected or transducted, MSCs can steadily express many therapeutic transgenes in vitro or in vivo as well. Furthermore, they have the ability to support hematopoietic system and participate in the process of inflammation in wound repair. Conclusion MSCs are stem cells which have the characteristic of self renewing, multi potency and easy to expand in vitro. MSCs are ideal target cells for cell and gene therapies. ?3/4 |
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| Keywords: | Marrow stromal cells Gene expression Differentiation |
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