膜联蛋白-1在食管鳞状细胞癌发生发展中的表达差异

目的　检测膜联蛋白 -1(annexin -1)在食管鳞状细胞癌及癌前病变中的表达差异。方法　应用免疫组化S -P方法检测 13 5例食管鳞状细胞癌及其癌旁正常鳞状上皮、原位癌及其不典型增生病变中annexin -1的表达情况。结果　annexin -1在 12 9例 (95 .6% )癌旁正常食管鳞状上皮呈强阳性表达 ;在 3 5例 (2 5 .9% )鳞状细胞癌呈阳性表达 ,60例 (4 4 .4% )为弱阳性 ,40例(2 9.6% )为阴性 ,统计学处理有极显著性差异 (P <0 .0 1)。食管鳞状细胞癌annexin -1表达下降与患者的年龄、性别、肿瘤分化程度及淋巴结转移无关 (P >0 .0 5 )。annexin -1在原位癌和不典型增生病变的表达亦呈下降趋势 ,与正常鳞状上皮比较有非常显著性差异 (P <0 .0 1)。结论　annexin -1蛋白在食管鳞状细胞癌和癌前病变中有不同程度的丢失 ,它很可能成为食管癌早期诊断以及预测食管癌前病变癌变风险的具有重要应用价值的指标

The Role of Annexin-1 in the Carcinogenesis of Esophageal Squamous Cell Carcinoma

Objective To detect the expression of annexin-1 in esophageal squamous cell carcinoma and precancerous lesions.Methods The immunohistochemistry S-P method was used to determine the expression of annexin-1 in 135 cases of esophageal squamous cell carcinoma,tumor surrounding normal squamous epithelium,precancerous lesions.Results Of the 135 cases of esophageal squamous cell carcinoma,the expression of annexin-1 was strongly positive in 35 cases(25.9%),weakly positive in 60 cases(44.4%) and negative in 40 cases(29.6%).In 135 specimens of tumor-surrounding normal epithelium,the expression of annexin-1 was strongly positive in 129 specimens(95.6%) and weakly positive in 6 specimens(6.4%).So the expression of annexin-1 decreased significantly in esophageal squamous cell carcinoma(P<0.01),and the decrease was not correlated with the age,sex,differentiation,and lymph node metastasis(P>0.05).Compared with normal squamous epithelium,the expression of annexin-1 dramatically decreased in the lesion of dysplasia and carcinoma in situ(P<0.01).Conclusion Annexin-1 may play an important role in early diagnosis of esophageal squamous cell carcinoma and in predicting the risk of carcinogenesis from precancerous lesions.