白细胞介素-13基因多态性与支气管哮喘的关系

支气管哮喘(哮喘)是常见的慢性呼吸道炎性疾病,其患病率在全球范围内有逐年增加的趋势。目前公认哮喘是一种受遗传因素和环境因素双重影响的多基因遗传病,近年发现某些细胞因子的遗传多态性与哮喘的发病存在一定的相关性。IL-13是一种典型的Th2细胞因子,可在效应阶段诱导出变应性哮喘的所有特征性症状。现发现与哮喘密切相关的IL-13基因位点约11个,其单核苷酸多态性与IL-13的表达、血清总免疫球蛋白水平及呼吸道高反应性密切相关。

Relationship between Interleukin- 13 Gene Polymorphisms and Bronchial Asthma

Bronchial asthma is a chronic inflammatory disorder of the airways.Its prevalence is showing an upward trend year by year and acutely threats the public health.At present,bronchial asthma is generally acknowledged a disease of multifactorial inheritance under the inf-luence of genetic factor and environmental agent.Cytokines play a part role in the pathogenesis of asthma and recent studies found there were some associations between the pathogenesis of asthma and polymorphisms of several cytokines.Interleukin-13(IL-β)is a typical cytokine of Th2.It can induce all characteristic symptoms of asthma in effector phase.It is found that eleven gene locus of IL-13 which has associations with the asthma.The mononucleotide of them is closely connected with expression of IL-13,the level of immunoglobulin in serum and airway hyper reactivity.