Quantitative dynamic contrast-enhanced MRI for the assessment of mandibular invasion by squamous cell carcinoma |
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| Authors: | Van Cann Ellen M Rijpkema Mark Heerschap Arend van der Bilt Andries Koole Ron Stoelinga Paul J W |
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| Affiliation: | aDepartment of Oral and Maxillofacial Surgery, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands;bDepartment of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands;cDepartment of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Geert Grooteplein 14, 6500 HB, Nijmegen, The Netherlands |
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| Abstract: | The objective of this study was to determine the value of dynamic contrast-enhanced MRI (DCE-MRI) for the preoperative assessment of mandibular invasion in squamous cell carcinomas (SCC), adjacent or fixed to the mandible. DCE-MRI was performed with gadolinium diethylene triamine pentaacetic acid (Gd-DTPA). Data were obtained from 25 patients. From pharmacokinetic analysis of the tissue uptake of Gd-DTPA, the DCE-MRI parameters (kep, Ktrans and ve) were determined, with kep representing the exchange rate constant, Ktrans the volume transfer constant and ve the volume of extracellular space per unit volume of tissue. The histology of the resection specimens was used as gold standard for the extent of mandibular invasion. SCC with medullary invasion showed higher mean kep and Ktrans compared with SCC without medullary invasion (ANOVA, p < 0.001). ROC analysis of kep and Ktrans revealed reliable threshold values for medullary invasion. In conclusion, DCE-MRI can discriminate SCC with medullary invasion from SCC without medullary invasion and may serve as a valuable tool in preoperative tumour staging with regard to the delineation of medullary invasion. |
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| Keywords: | Magnetic resonance imaging DCE-MRI Mandibular invasion Squamous cell carcinoma Oral and oropharyngeal cancer |
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