米氮平治疗惊恐障碍患者对照研究

目的：探讨米氮平对惊恐障碍患的疗效及副作用。方法：对40例惊恐障碍患随机分成米氮平治疗组、帕罗西汀治疗组．并用HAMA、GAS、SERS对患治疗前后进行评估。结果：在疗效方面，两组患的HAMA及GAS分在不同治疗时期无显性差异。治疗6周末．以HAMA减分率判断，米氮平组患的有效率为94．44％．治愈率为72．22％．而且米氮平组与帕罗西汀组患的有效率及治愈率亦无显性差异。在副作用方面，两组患也没有显差异。结论：米氮平治疗惊恐障碍患疗效及副作用与帕罗西汀相当。

The control study of Mirtazapine in treating the patients with panic Disorder

Objective: To investigate the clinical and side effects of Mirtazapine in treating the patients with panic disorder. Methods: 40 patients with panic disorder were divided into two groups randomly. The patients of study group were treated by Mirtazapine; Paroxetine in the control group. All subjects were rated by the Hamilton Anxiety Scale (HAMA) , Global Assessment Scale (GAS), Rating Scale for Side Effects (SERS) at the baseline and at the end of week one, two, four, six respectively. Results: The response rate and remission rate were 94. 44%, 72. 22% respectively in the study group at the end of the sixth week according to the change of HAMA. There were no significant differences between the tow groups in both clinical effects and side effects. Conclusions: The clinical and side effects of Mirtazapine in treating the patients with panic disorder were similar to those of Paroxetine.