胆红素致新生兔脑瘫动物模型的实验研究

为研制胆红素致脑瘫动物模型，将新生２４ｈ内的仔兔３０只分为正常组Ａ，实验组Ｂ、Ｃ各１０只。实验组Ｂ、Ｃ分别腹腔注射胆红素１００、３００ｍｇ／ｋｇ，正常组与实验组仔兔自然哺育４５ｄ后对其进行神经行为学检查和评分。结果：实验组Ｂ仔兔神经行为得分与正常组Ａ相比差异无显著意义；实验组Ｃ卫兔神经行为得分与正常组Ａ相比差异有非常显著意义；实验组Ｃ中有８只仔兔神经行为得分较高，但与正常组Ａ相比差异仍有非常显著意

A Study on the Animal Model of Bilirubin-induced Cerebral Palsy in Newborn Rabbits

In an attempt to develop an animal model of bilirubin-induced cerebral palsy, 30 newborn rabbits (age <24h) were divided into three groups (A: normal control group; B and C: experimental group, n= 10 in each). The rabbits in groups B and C were administered with bilirubin intraperitoneally 100 mg/kg and 300 mg/kg respec- tively. The neural behaviors of all animals were checked and their scores given after being fed naturally for 45 days.It was found that there was a significant difference between A and C groups in scores of neural behavior. Eight rab- bits in group C had higher scores, but there was a significant difference between groups A and C, the remaining 2 rabbits had lower scores of the behavior. abnormal movement and posture. These results suggested that bilirubin (i. p. 300 mg/kg) could cause brain damage of newborn rabbits and induce cerebral palsy.