巴尼地平自微乳化液大鼠在体小肠吸收动力学研究

目的：通过大鼠在体小肠吸收实验方法，研究巴尼地平自微乳大鼠小肠吸收动力学。方法：以微乳肠循环液中的巴尼地平含量为指标，计算吸收速率常数（Ka）以及3h的吸收百分数（PA）。结果：巴尼地平自微乳肠循环液灌流3h后，胆管结扎的大鼠小肠药物吸收百分率为80．73％，胆管未结扎的大鼠小肠药物吸收百分率为81．74％。结论：巴尼地平自微乳化液透膜性好．吸收较快。胆管结扎与否小肠吸收率无显著影响（P〉0．05）。

Studies on Absorption Kinetics of Barnidipine Self-microemulsion on the Small Intestine of Rats

Objective： To study the absorption kinetics of barnidipine self-microemulsion on the small intestine of rats. Method： The absorption rate （Ka） and the percentage of 3h absorption（PA） in the intestinal fluid were calculated by using the content of barni- dipine as index. Result： The absorption rates were 80.73% and 81.74% after bamidipine perfusion for 3 h in with and without the bile duct ligated, respectively. Conclusion： Barnidipine self-microemulsion has good membrane permeability, and absorps rapidly. There is no significant impact on the absorption rate （ P 〉 0. 05 ） whether the bile duct is ligated or not.