醋酸地塞米松对替硝唑大鼠体内药动学的影响

目的：探讨醋酸地塞米松对替硝唑大鼠体内药动学的影响。方法：大鼠随机分为两组，每组5只，一组灌胃给予替硝唑，另一组灌胃给予醋酸地塞米松，连续5d，于第6天合并给药替硝唑与醋酸地塞米松，分别测定两组大鼠血浆中替硝唑的浓度，用DAS软件程拟合药动学参数。结果：单独给予替硝唑组和联合给药组的替硝唑的主要药动学参数：Cmax分别为（27．08±2．98）和（23．69±3．45）mg·L^-1,t1／2：（2．16±0．76）h和（1．95±0．31）h，AUC0-24h（138．04±5．84）和（119．90±11．46）mg·h·L^-1。两组间AUC及CL／F的差异有统计学意义（P〈0．05）。结论：醋酸地塞米松对替硝唑大鼠体内药动学过程影响较小。

Effect of Dexamethasone Acetate on the Pharmacokinetic of Tinidazole in Rats

Objective： To study the effect of dexamethasone acetate on the phal-macokinetic of tinidazole in rats. Method ： Ten rats were randomly divided into two equal groups ： A and B. Rats of group A were given tinidazole. Rats of group B were given dexamethasone acetate for five days, and tinidazole was given at the sixth day with the dexamethasone acetate. Blood samples were taken from the animals for the determination of the plasma concentration of tinidazole by HPLC. The pharmacokinetics parameters were calculated by DAS software. Result： The main pharmacokinetics parameters of group A were as follows： Cmax were （27.08 ± 2. 98） mg·L^-1 ,t1/2 were （2. 16 ± 0.76） h,AUC0-24 h were （ 138.04 ± 5.84 ） mg·h^-1·L^- 1. The main pharmacokinetics parameters of group B were as follows ： Cmax were （ 23.69 ±3.45 ） mg. L^-1 , t 1/2 were （ 1.95 ±0. 31 ） h, A UC0-24 h were （ 119. 90 ± 11.46 ） mg. h^- 1·L^ - 1. The results showed that the main pharmacokinetic parameters of tinidazole have significant differences between two groups. Conclusion： Dexamethasone acetate has little effect on the pharmacokinetic of tinidazole in rats.