| 红外光谱法测定硅酮二号凝胶中二甲硅油的含量 |
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| 引用本文： | 杨婉花,张芳华. 红外光谱法测定硅酮二号凝胶中二甲硅油的含量[J]. 中国药师, 2010, 13(11): 1621-1623 |
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| 作者姓名： | 杨婉花 张芳华 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院药剂科,上海200025 |
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| 摘 要： | 目的：建立红外光谱法（IR）测定硅酮二号凝胶中二甲硅油含量的方法。方法：采用红外分光光度仪，样品用甲苯作提取剂．在1262cm^-1。波数处测定二甲硅油的含量。结果：二甲硅油在0．41～2．86mg·ml^-1浓度范围内与吸光度呈良好的线性关系（r=0．9999，n=7），平均回收率为99．97％，RSD=0．94％（n=6）。结论：该方法简便，准确、重复性好，可用于该制剂的含量测定。
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| 关 键 词： | 红外光谱法 硅酮二号凝胶 二甲硅油 含量测定 |
Determination of Ploydimethyl Siloxane Fluid in Silicone No.2 Gel by Infrared Spectrometry |
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| Yang Wanhua,Zhang Fanghua. Determination of Ploydimethyl Siloxane Fluid in Silicone No.2 Gel by Infrared Spectrometry[J]. China Pharmacist, 2010, 13(11): 1621-1623 |
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| Authors: | Yang Wanhua Zhang Fanghua |
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| Affiliation: | ( Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China) |
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| Abstract: | Objective： To establish the IR method for determination of ploydimethyl siloxane fluid in Silicone No2 gel. Method： Silicone No2 gel was solved and extracted by toluene. The characteristic absorption peak at 1 262cm- 1 for Si-CH3 bond in ploydimethyl siloxane fluid was used as the quantitative determination. Result： The linear range of ploydimethyl siloxane fluid was 0. 41-2. 86 mg· ml ^-1（ r = 0. 999 9, n = 7 ）. The average recovery was 99. 97% ,RSD was 0. 94% （ n = 6 ）. Conclusion ： The method is accurate, reliable and quick, and can be applied to determination the content of ploydimethyl siloxane fluid in Silicone No2. gel. |
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| Keywords: | Infrared spectrometry Silicone No2 gel Ploydimethyl siloxane fluid Determination |
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