血栓通注射液对犬脑循环的影响研究

目的：观察血栓通注射液（XST）对麻醉犬脑循环的影响。方法：杂种犬24条，随机分为对照组、血栓通注射液低、中、高剂量组，单次左侧股静脉滴注给药（匀速滴注15min）观察收缩压（SAP）、舒张压（DAP）、平均动脉血压（MAP）、心率（HR）、脑血流量（CBF）、脑血管阻力（CVR）和颈内动脉流量等指标的变化。结果：血栓通注射液10、20mg·kg^-1在静脉滴注给药后10—30min均能明显增加脑血流量和颈内动脉流量，降低脑血管阻力（P〈0．05）。各剂量组对血压、心率影响均不明显（P〉0．05）。结论：血栓通注射液能明显增加脑血流量和颈内动脉流量，降低脑血管阻力，具有改善麻醉犬脑循环的作用。

Effect of Xueshuantong Injection on Brain Circulation in Anesthetized Dogs

Objective： To observe the effect of xueshuantong injection on brain circulation in anesthetized dogs. Method ： Twenty four hybrid dogs, were randomly divided into control group and 3 groups treated with xuesbuantong low-dose group （5 mg·kg^-1 ）, middle-dose group （10 mg·kg^-1） ,high-dose group （20 mg·kg^-1） ,the changers of SAP,DAP,MAP,HR,CBF,CVR, internal carotid artery flow were observed after femoral venous administration （uniform drip 15 min）. Result： Cerebral blood stream and internal carotid artery flow were obviously increased in animals treated with xueshuantong injection 10 and 20 mg·kg^-1 groups during 10-30 min after drug intravenous administration with differences from those before giving the drug （ P 〈 0. 05 ） ; Moreover, blood pressure and heart rate in three xueshuantong injection groups had no significant effect before and after giving the drug （ P 〉 0.05 ）. Conclusion ： Xueshuan- tong injection can increase cerebral blood stream and internal carotid artery flow, reduce cerebral blood vessel resistance and improve its＇ circulation.