| 酮洛芬缓释片的制备及其体外释放度考察 |
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| 引用本文： | 李春雷,郑芳,李志浩,李鹏,朱雪松. 酮洛芬缓释片的制备及其体外释放度考察[J]. 中国药师, 2010, 13(11): 1630-1632 |
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| 作者姓名： | 李春雷 郑芳 李志浩 李鹏 朱雪松 |
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| 作者单位： | 湖北医药学院附属东风医院,湖北十堰442008 |
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| 摘 要： | 目的：优化筛选酮洛芬缓释片的处方。方法：以体外释放度为指标，采用正交设计法优化酮洛芬缓释片的处方，并考察酮洛芬缓释片体外的释放机制。结果：最佳处方为：酮洛芬110g，羟丙甲纤维素（HPMC）20g，乳糖30g，乙基纤维素（EC）40g。酮洛芬缓释片体外释放行为符合Higuchi方程。结论：酮洛芬缓释片处方合理，工艺简单，缓释效果较好。
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| 关 键 词： | 酮洛芬 正交设计 缓释片 释放度 |
Preparation of Ketoprofen Sustained-release Tablets and Its Release Property in vitro |
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| Li Chunlei,Zheng Fang,Li Zhihao,Li Peng,Zhu Xuesong. Preparation of Ketoprofen Sustained-release Tablets and Its Release Property in vitro[J]. China Pharmacist, 2010, 13(11): 1630-1632 |
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| Authors: | Li Chunlei Zheng Fang Li Zhihao Li Peng Zhu Xuesong |
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| Affiliation: | (Department of Pharmacy, Dongfeng Hospital, Hubei Medical University, Hubei Shiyan 442008, China) |
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| Abstract: | Objective ： To optimize the formulation of ketoprofen sustained-release tablets. Method ： The cumulative release in vitro of the ketoprofen sustained-release tablets was studied as the evaluation parameter, its formulation was optimized by the orthogonal design method and its release mechanism in vitro was also studied. Result： The optimal formulation of ketoprofen sustained-release tablets composed of ketoprofen 110 g,HPMC 20 g,lactose 30 g, EC 40 g and its release mechanism followed Higuchi kinetic equation. Conclusion： The formulation of ketoDrofen sastained-release tablets is feasihle with favorable release and rational preparing technology. |
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| Keywords: | Ketoprofen Orthogonal design Sustained-release tablet Release |
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