大果阿魏抗凝血活性实验

目的：研究大果阿魏的抗凝血作用。方法：Wistar大鼠随机分为6组，大果阿魏高剂量组100mg·kg^-1，中剂量组50mg·kg^-1，低剂量组25mg·kg^-1，中药阳性药物对照组银杏叶片144μg·kg^-1，西药阳性药物对照组华法林125μg·kg^-1，空白溶剂对照组给予等容量的生理盐水，连续灌胃7d。测定大鼠活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）及复钙时间（RT），观察大果阿魏的抗凝血作用。结果：高、中、低三个剂量组的大果阿魏均能明显延长大鼠血浆APTT、PT、TT和RT时间。与溶剂对照组比较，差异均有统计学意义（P〈0．05或P〈0．01）。结论：大果阿魏具有显著的抗凝血作用。

Study on Anticoagulation Effects of Ferula lehmannii Boiss

Objective ： To study the effect of FerulA lehmannii Boiss on anticoagulation. Method ： Wistar mice were randomly allocated to six groups. Ferula lehmannii Boiss group received the Ferula lehmannii Boiss at a dose level of 100, 50, 25 mg. kg- 1 by intragastric administration for seven days. Warfarin group was given warfarin sodium tablets at a dose level of 144 μg. kg- 1 for seven days. ginkgo leaf group was given ginkgo leaf tablets at a dose level of 125 μg.kg-1 for seven days. Control group was kept in an equal vol- ume of normal saline. AFTT, PT, TT, RT were used to evaluate the anticoagulalion activities of Ferula lehmannii Boiss. Result： Feru- la lehmannii Boiss significantly delayed APTT, PT, TT and RT. Compared with control group of NS, the difference had statistical significance （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion： Ferula lehmannii Boiss has obvious effect on blood antieoagulation.