| 更昔洛韦药物树脂的制备及表征 |
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| 引用本文： | 周伟,谢欢,刘姹,杨大坚,陈新滋.更昔洛韦药物树脂的制备及表征[J].中国药师,2010,13(11):1559-1562. |
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| 作者姓名： | 周伟 谢欢 刘姹 杨大坚 陈新滋 |
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| 作者单位： | 深圳市中药药学及分子药理学研究重点试验室,广东深圳518057 |
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| 摘 要： | 的：研究将更昔洛韦制备成药物树脂复合物。方法：优选药物树脂复合物的制备方法，对药物树脂复合物进行红外光谱分析、差示热分析和热重分析。结果：动态交换法的优化条件为药物浓度4mg·ml^-1，树脂粒径为200～300目，流速1ml·min^-1。结论：动态交换法优于静态交换法，树脂与药物通过离子键的化学吸附结合。
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| 关 键 词： | 更昔洛韦 离子交换树脂 动态交换法 表征 |
Preparation and Characteristics of Ganciclovir Resins |
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| Zhou Wei,Xie Huan,Liu Cha,Yang Dajian,Chen Xinzi.Preparation and Characteristics of Ganciclovir Resins[J].China Pharmacist,2010,13(11):1559-1562. |
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| Authors: | Zhou Wei Xie Huan Liu Cha Yang Dajian Chen Xinzi |
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| Institution: | (State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Guangdong Shenzhen 518057,China) |
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| Abstract: | Objective： To prepare the gancicloveir resins. Method： The method of drug-resin complexes preparation was opti- mized, the ganciclovir resins were analized by IR-spectrum, DSC and TG analysis. Result： The drug concentration that prepared the gancicloveir resins was 4 mg· ml - 1 and the resin particle size was 200-300 screen mesh, the efflux speed was 1 ml· min - 1. Conclusion： The column method is better than the bath method,the drug and resins combine with chemistry absorb of electrovalent bond. |
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| Keywords: | Ganciclovir Ion exchange resin Bath method Characteristics |
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