HPLC法测定布南色林片的含量

目的：建立以高效液相色谱法测定布南色林片含量的方法。方法：以Kromasil C18（250mm×4．6mm，5μm）为色谱柱，流动相为乙腈-甲醇-25mmol·L^-1磷酸二氢钠溶液（35：30：35），检测波长为243nm，流速为1ml·min^-1，柱温为30℃。结果：布南色林在0．0251～0．2092μg范围内进样量与峰面积呈良好的线性关系（r=0．9999），平均回收率为100．1％，RSD=0．6％。结论：本方法简便、准确、专属性强，可用于该制剂的质量控制

Determination of Blonanserin Tablets by HPLC

Objective： To establish an HPLC method for determination of blonanserin in blonanserin tablets. Method： HPLC was performed on a Kromasil C18 colunm（250 mm × 4. 6 mm,5 μm） with acetonitrile-methanol-25 mmol· L^-1 natrium dihydrogen phosphate solution （35： 30：35 ） as the mobile phase at a flow rate of 1.0 ml· min^-1. The detection wavelength was at 243 nm and the column temperature was 30 ℃. Result： The linear range of blonanserin was 0. 025 1-0. 209 2 μg （r = 0. 999 9 ）, the average recovery was 100. 1% （RSD = 0. 6% ）. Conclusion： The method is simple, accurate, special and can be used for the quality control of blonanserin tablets.