磁共振成像(MRI)对前列腺癌分期的临床意义(英文)

目的探讨临床分期和磁共振成像(MRI)分期预测前列腺癌病理分期的临床意义。方法对32例病理证实的局限性前列腺癌行根治性手术前经直肠指诊进行临床分期及 MRI 分期预测术后前列腺病理分期结果,评价其预测前列腺癌病理分期的诊断性结果。结果本组32例前列腺癌中,临床分期局限于前列腺内的肿瘤(B 期)30例,10例前列腺癌根治术后病理诊断有前列腺包膜及包膜外浸润,1例左髂血管旁淋巴结转移癌,36.7%(11/30)病例临床分期偏低,2例临床分期为 C 期病例术后1例为 B 期,临床分期偏高。而 MRI 诊断的30例前列腺癌中,分期局限于前列腺内的肿瘤(B 期)21例中,4例前列腺根治术后病理诊断为 C 期,19.1%(4/21)的病例 MRI 分期偏低;9例 MRI 分期为 C 期病例1例术后为 B 期,分期偏高,另1例术后为 D1期,分期偏低。直肠指诊临床分期和 MRI 分期预测前列腺癌的病理结果有显著相关性(P=0.002)。临床分期和 MRI 分期对局限于前列腺内肿瘤的预测(PPV)分别为63.3%和80.9%;对浸润包膜及包膜外肿瘤的预测(NPV)分别为50.0%和88.9%、MRI 对前列腺癌病理分期的预测更具有特异性和较高的准确性,能更好的预测前列腺癌的病理结果(P=0.023)。结论 MRI 分期较直肠指诊临床分期能更好地预测局限于前列腺内的肿瘤,对前列腺包膜及包膜以外浸润的肿瘤能进行更准确的分期。

Evaluation of Clinical and MRI Staging for Prostate Cancer before Radical Prostatectomy

Objective:To evaluate the clinical significance of clinical staging and magnetic resonance imag- ing(MRI)staging for prostate cancer before radical prostatectomy.Methods:Thirty-two patients with organ confined prostate cancer were reviewed to assess the accuracy of clinical staging and MRI staging to correlate with pathological staging results after radical prostatectomy.Results:33.3%(10/30)prostate cancer patients with staging C and 3.3%(1/30)prostate cancer patients with staging D were diagnosed by pathology after radical prostatectomy in 30 patients with prostate cancer with clinical staging B,and 36.7%(11/30)under staging;Only one patient was over staging in clinical staging C.19.1%(4/21)prostate cancer patients with staging C were diagnosed in 21 patients with prostate cancer and under staging with MRI staging B;11.1%(1/9)was over staging with MRI staging C.The clinical staging and MRI staging had more correlation with pathological staging results(P=0.002),and PPV of the organ confined prostate cancer by clinical staging and MRI staging were 63.3% and 80.9% respectively,and NPV of nonorgan confined prostate cancer by clinical staging and MRI staging were 50% and 88.9% respectively.MRI stag- ing was more specificity and accuracy than that of clinical staging to predict pathological staging results before radical prostatectomy(P=0.023).Conclusion:The MRI staging was more accuracy than that of clinical staging to predict pathological staging results in organ confined and nonorgan confined prostate cancer before radical prostatectomv.